한빛사 논문
Abstract
Hyun Seok Kim,1 John D. Minna,2,3 and Michael A. White1,3,*
1Department of Cell Biology
2Departments of Internal Medicine and Pharmacology and Hamon Center for Therapeutic Oncology Research
3Simmons Comprehensive Cancer Center
University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA
*Correspondence: Michael A. White
Summary
Genome-wide association studies (GWASs) have unraveled a large number of cancer risk alleles. Understanding how these allelic variants predispose to disease is a major bottleneck confronting translational application. In this issue, Li and colleagues combine GWASs with The Cancer Genome Atlas (TCGA) to disambiguate the contributions of germline and somatic variants to tumorigenic gene expression programs. They find that close to half of the known risk alleles for estrogen receptor (ER)-positive breast cancer are expression quantitative trait loci (eQTLs) acting upon major determinants of gene expression in tumors.
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