한빛사 논문
Abstract
Elaine C. Budrecka,1, Oh-Bin Kwonb,1, Jung Hoon Jungb, Stephane Baudouina, Albert Thommena, Hye-Sun Kimc, Yugo Fukazawad,e, Harumi Haradad,e, Katsuhiko Tabuchid,e,f, Ryuichi Shigemotod,e,g, Peter Scheiffelea,2, and Joung-Hun Kimb,2
aBiozentrum, University of Basel, 4056 Basel, Switzerland;
bDepartment of Life Science, Pohang University of Science and Technology (POSTECH), Pohang, Gyungbuk 790-784, Korea;
cDepartment of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799, Korea;
dDivision of Cerebral Structure, National Institute for Physiological Sciences, Okazaki 444-8787, Japan;
eDepartment of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8787, Japan;
fPrecursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Saitama 332-0012, Japan; and
gSolution Oriented Research for Science and Technology (SORST), Japan Science and Technology Agency, Kawaguchi 333-0012, Japan
Edited by Michael Eldon Greenberg, Harvard Medical School, Boston, MA, and approved November 28, 2012 (received for review August 28, 2012)
Abstract
Despite the pivotal functions of the NMDA receptor (NMDAR) for neural circuit development and synaptic plasticity, the molecular mechanisms underlying the dynamics of NMDAR trafficking are poorly understood. The cell adhesion molecule neuroligin-1 (NL1) modifies NMDAR-dependent synaptic transmission and synaptic plasticity, but it is unclear whether NL1 controls synaptic accumulation or function of the receptors. Here, we provide evidence that NL1 regulates the abundance of NMDARs at postsynaptic sites. This function relies on extracellular, NL1 isoform-specific sequences that facilitate biochemical interactions between NL1 and the NMDAR GluN1 subunit. Our work uncovers NL1 isoform-specific cis-interactions with ionotropic glutamate receptors as a key mechanism for controlling synaptic properties.
synapse, neurotranmitter receptor, neurexin
1E.C.B. and O.-B.K. contributed equally to this work.
2To whom correspondence may be addressed.
Author contributions: E.C.B., O.-B.K., P.S., and J.-H.K. designed research; E.C.B., O.-B.K., J.H.J., S.B., A.T., Y.F., H.H., and K.T. performed research; E.C.B., O.-B.K., and R.S. analyzed data; H.-S.K. and R.S. contributed new reagents/analytic tools; and P.S. and J.-H.K. wrote the paper.
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