Dr. Chi Kyung Kim1,‡, Taeho Kim2,‡, In-Young Choi1, Min Soh2, Dr. Dohoung Kim1, Young-Ju Kim1, Dr. Hyunduk Jang1, Hye-Sung Yang1, Dr. Jun Yup Kim1, Dr. Hong-Kyun Park1, Dr. Seung Pyo Park2, Sangseung Park2, Dr. Taekyung Yu2, Prof. Byung-Woo Yoon1, Prof. Seung-Hoon Lee1,*, Prof. Taeghwan Hyeon2,*
1Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)
2Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)
‡These authors contributed equally to this work.
†This work was supported by a grant of the Korean Health Technology R&D Project, Korean Ministry of Health & Welfare (A111014).
Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.
Keywords:apoptosis;ceria nanoparticles;ischemic stroke;reactive oxygen species;therapeutic agents