한빛사 논문
Abstract
Ji Hyun Kim‡, Young-Woock Noh‡, Min Beom Heo, Mi Young Cho, Prof. Dr. Yong Taik Lim*
Graduate School and Department of Analytical Science and Technology, Chungnam National University, Daejeon 305-764 (Republic of Korea)
‡These authors contributed equally to this work.
* To whom correspondence may be addressed.
†We acknowledge financial support from the National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (No. 2010-0026793), (2009, University-Institute cooperation program), the National Agenda Project grant from Korea Research Council of Fundamental Science and Technology, the grant from Korea Basic Science Institute (T32403), and the Korea Health Technology R&D Project, Ministry of Health & Welfare (No. A111918).
A winning combination: Multifunctional hybrid nanoconjugates (HNCs) based on polymer nanoparticles containing quantum dots (QDs) conjugated with CpG oligonucleotides (as a ligand for TLR9) and STAT3 siRNAs (to suppress the immune response) have been synthesized (see scheme). These HNCs were shown to synergistically enhance the antitumor immune response in dendritic cells and in tumor-bearing mice.
Keywords:antitumor agents;dendritic cells;drug delivery;fluorescent probes;hybrid nanoconjugates
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