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Abstract
Eun Jung Lee1, Keum-Young Ahn1, Jong-Hwan Lee1, Jin-Seung Park1, Jong-Am Song1, Sang Jun Sim1, Eun Bong Lee2, Young Joo Cha3, Jeewon Lee1,*
1Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea
2College of Medicine, Seoul National University, Daehak-Ro 103, Seoul 110-744, Republic of Korea
3College of Medicine, Chung-ang University, Heuksuk-Ro 84, Seoul 156-756, Republic of Korea
*Correspondence and requests for reprints should be addressed to Jeewon Lee
Ferritin-based nanoprobe (FBNP) hydrogel provides solutions to some of the traditional problems of bioassays. The schematic shows 3D and highly specific multiplex assays of markers for AIDS and Sjogren's syndrome using quantum-dot based reporters with different fluorescence emissions for the two syndromes. The advantages of using a hydrogel include that the stability of FBNPs is significantly enhanced within the hydrogel, FBNPs are distributed evenly throughout the hydrogel matrix, and the amount of FBNPs within the hydrogel can be well controlled.
Keywords : ferritin; nanoprobes; hydrogels; bioassay platforms; biomedical applications
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