한빛사 논문
Abstract
Ju Hee Ryua, 1, Heebeom Kooa, 1, In-Cheol Suna, Soon Hong Yukb, Kuiwon Choia, Kwangmeyung Kima, Ick Chan Kwona,*
a Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 6, Seongbuk-gu, Seoul 136-791, Republic of Korea
b College of Pharmacy, Korea University, Jochiwon, Yeongi, Chungnam 339-700, Republic of Korea
*Corresponding author : Ick Chan Kwon
1Authors contributed equally.
Abstract
Theragnostic nanoparticles (NPs) contain diagnostic and therapeutic functions in one integrated system, enabling diagnosis, therapy, and monitoring of therapeutic response at the same time. For diagnostic function, theragnostic NPs require to include noninvasive imaging modalities. Among them, optical imaging has various advantages including sensitivity, real-time and convenient use, and non-ionization safety, which make it the leading technique for theragnostic NPs. For therapeutic function, theragnostic NPs have been applied to chemotherapy, photodynamic therapy, siRNA therapy and photothermal therapy. In this review, we present a recent progress reported in the development and applications of theragnostic NPs for cancer therapy. More specifically, we will focus on theragnostic NPs related with optical imaging, highlighting promising strategies based on optical imaging techniques.
Keywords
Theragnosis; Chemotherapy; Photodynamic therapy; siRNA therapy; Photothermal therapy; Optical imaging; Personalized medicine; Molecular imaging; Cancer; Nanomedicine
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