한빛사 논문
Abstract
Eun-Kyung Lim1, Yong-Min Huh2,3,4, Jaemoon Yang2,3, Kwangyeol Lee5, Jin-Suck Suh2,3,4,*, Seungjoo Haam1,3,*
1Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Republic of Korea
2Department of Radiology, Yonsei University, Seoul 120-752, Republic of Korea
3YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752, Republic of Korea
4Severance Biomedical Science Institute(SBSI), Seoul 120-752, Republic of Korea
5Department of Chemistry, Korea University, Seoul 136-701, Republic of Korea
*Corresponding authors
pH-sensitive drug-delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug release kinetics of the DMNPs, combined with the nanoparticle accumulation pattern in tumor cells, can be monitored by magnetic resonance imaging (MRI) to guide decisions regarding the optimization of drug dosing schedules.
Keywords:theragnostics;nanoparticles;magnetic resonance imaging;drug delivery
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