Young-Ki Paik¹, Seul-Ki Jeong¹, Gilbert S Omenn^2,3, Mathias Uhlen⁴, Samir Hanash⁵, Sang Yun Cho^1,13, Hyoung-Joo Lee¹, Keun Na¹, Eun-Young Choi¹, Fangfei Yan⁶, Fan Zhang⁶, Yue Zhang⁶, Michael Snyder⁷, Yong Cheng⁷, Rui Chen⁷, Gyorgy Marko-Varga⁸, Eric W Deutsch³, Hoguen Kim⁹, Ja-Young Kwon⁹, Ruedi Aebersold¹⁰, Amos Bairoch¹¹, Allen D Taylor⁴, Kwang Youl Kim¹, Eun-Young Lee¹, Denis  Hochstrasser¹¹, Pierre Legrain¹² & William S. Hancock^1,5

¹Yonsei Proteome Research Center, Yonsei University, Seoul, Korea. ²Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. ³Institute for Systems Biology, Seattle, Washington, USA. ⁴Royal Institute of Technology, Stockholm, Sweden. ⁵Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. ⁶Northeastern University, Boston, Massachusetts, USA. ⁷Stanford University, Palo Alto, California, USA. ⁸Lund University, Lund, Sweden. ⁹Yonsei University College of Medicine, Seoul, Korea. ¹⁰Department of Biology, Institute of Molecular Systems Biology, Eidgenossische Technische Hochschule, Zurich, Switzerland, and Faculty of Science, University of Zurich, Zurich, Switzerland. ¹¹Swiss Institute of Bioinformatics and University of Geneva, Geneva, Switzerland. ¹²Ecole Polytechnique, Palaiseau, France. ¹³Present address: Korean National Institute of Health, Osong, Korea.

Correspondence to: Young-Ki Paik orWilliam S. Hancock

The Chromosome-Centric Human Proteome Project (C-HPP) aims to define the full set of proteins encoded in each chromosome through development of a standardized approach for analyzing the massive proteomic data sets currently being generated from dedicated efforts of national and international teams. The initial goal of the C-HPP is to identify at least one representative protein encoded by each of the approximately 20,300 human genes^{1, 2}. The proteins will be characterized for tissue localization and major isoforms, including post-translational modifications (PTMs), using quantitative mass spectrometry and antibody reagents. Our rationale is that effective integration of proteomics data into a genomic framework will lead to improved knowledge of complex biological systems and facilitate access to protein level data. Although the intent to engage in a C-HPP program has been noted^{1, 2, 3}, our objective here is to define the goals and process for its development as a multinational program.