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Abstract
Gyeong-Su Park*†, Hyuksang Kwon‡, Dong Wook Kwak§, Seong Yong Park†, Minseok Kim†, Jun-Ho Lee†, Hyouksoo Han†, Sung Heo†, Xiang Shu Li†, Jae Hak Lee†, Young Hwan Kim†, Jeong-Gun Lee†, Woochul Yang§, Hoon Young Cho§, Seong Keun Kim*‡, and Kinam Kim†
†Samsung Advanced Institute of Technology, San 14?1, Nong-Seo Ri, Ki-Hung Eub, Yong-In Gun, Kyung-Ki Do 449-900, South Korea
‡ Department of Chemistry and WCU Department of Biophysics and Chemical Biology, Seoul National University, Seoul 151-747, South Korea
§ Department of Physics, Dongguk University, Seoul 100-715, South Korea
Author Contributions : G.-S.P., S.K.K.
These authors contributed equally to this work.
Abstract
We report on rapid thermal chemical vapor deposition growth of silicon nanowires (Si NWs) that contain a high density of gold nanoclusters (Au NCs) with a uniform coverage over the entire length of the nanowire sidewalls. The Au NC-coated Si NWs with an antibody-coated surface obtain the unique capability to capture breast cancer cells at twice the highest efficiency currently achievable (~88% at 40 min cell incubation time) from a nanostructured substrate. We also found that irradiation of breast cancer cells captured on Au NC-coated Si NWs with a near-infrared light resulted in a high mortality rate of these cancer cells, raising a fine prospect for simultaneous capture and plasmonic photothermal therapy for circulating tumor cells.
Keywords: Si nanowire; RTCVD; gold nanocluster; breast cancer cells; photothermal therapy
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