Jinju Han, Ahmet M. Denli and Fred H. Gage1
Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
Differentiation of multipotent stem cells occurs through the highly coordinated control of gene expression. Repressor element 1 (RE1) silencing transcription factor (REST), a master transcriptional regulator in neuronal stem cells, restricts neuronal gene expression. REST activity is context-dependent and is modified by its cofactors, such as Ctdsp2. In this issue of Genes & Development, Dill and colleagues (pp. 25-30) report on the microRNA-mediated regulation of neural differentiation. Interestingly, this microRNA is post-transcriptionally regulated and modulates expression of its host gene, ctdsp2.
miR-26b, ctdsp2, REST, neurogenesis, neuronal differentiation, zebrafish
1 Corresponding author.