한빛사 논문
Abstract
Joseph Park1,‡, Prof. Jaemoon Yang2,4,‡, Eun-Kyung Lim1, Eunjung Kim1, Jihye Choi1, Joo Kyung Ryu3, Nam Hee Kim3, Prof. Jin-Suck Suh2,4,5, Prof. Jong In Yook3, Prof. Yong-Min Huh2,4,5,*, Prof. Seungjoo Haam1,4,*
1Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749 (Republic of Korea)
2Department of Radiology, Yonsei University, Seoul 120-752 (Republic of Korea)
3Department of Oral pathology, Oral Cancer Research Institute, Yonsei University, Seoul 120-752 (Republic of Korea)
4YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752 (Republic of Korea)
5Severance Biomedical Science Institute (SBSI), Seoul 120-749 (Republic of Korea)
*Correspondence: Prof. Seungjoo Haam, Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749 (Republic of Korea)
*Correspondence: Prof. Yong-Min Huh, Department of Radiology, Yonsei University, Seoul 120-752 (Republic of Korea)
Activatable nanoprobe: A dual-function nanoprobe has been developed that detects membrane type 1-matrix metalloproteinase (MT1-MMP) activity by a dual-signal increase in complementary fluorescence imaging (FI) and magnetic resonance imaging (MRI). MNCs=magnetic nanocrystals, Q=quencher, F=fluorescence dye.
Keywords:cancer;fluorogenic probes;magnetic resonance imaging;MT1-MMP;nanoprobes
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