한빛사 논문
Abstract
Kyungtae Kang1,‡, Sung-Eun Choi3,‡, Hee Su Jang3, Dr. Woo Kyung Cho1, Prof. Dr. Yoonkey Nam2,*, Prof. Dr. Insung S. Choi1,2,*, Prof. Dr. Jin Seok Lee3,*
1Molecular-Level Interface Research Center, Department of Chemistry, KAIST, Daejeon 305-701 (Korea)
2Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 (Korea)
3Department of Chemistry, Sookmyung Women’s University, Seoul 140-742 (Korea)
*Correspondence: Prof. Dr. Insung S. Choi, Molecular-Level Interface Research Center, Department of Chemistry, KAIST, Daejeon 305-701 (Korea)
*Correspondence: Prof. Dr. Yoonkey Nam, Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 (Korea)
*Correspondence: Prof. Dr. Jin Seok Lee, Department of Chemistry, Sookmyung Women’s University, Seoul 140-742 (Korea)
Something to sprout about: The developmental acceleration of hippocampal neurons occurred on well-packed structures of silica beads with diameters over 200 nm (see picture; scale bar: 5 um, inset scale bar: 1 um). The neurons sensed the size differences of the nanostructures and altered their behaviors, thus implying that nanotopographical stimuli are one of the important features for guiding neurites during neural developments in vivo.
Keywords:axon outgrowth;cytoskeletal proteins;nanostructures;neurochemistry;silica bead
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