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Abstract
Seung Chul Shin1,3,*,†, Sung-Hee Kim1,†, Hyejin You1,2, Boram Kim1,2, Aeri C. Kim1,2, Kyung-Ah Lee1, Joo-Heon Yoon3, Ji-Hwan Ryu3, Won-Jae Lee1,‡
1School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul 151-742, South Korea.
2Department of Bioinspired Science and Division of Life and Pharmaceutical Science, Ewha Woman’s University, Seoul 120-750, South Korea.
3Research Center for Human Natural Defense System, Yonsei University College of Medicine, CPO Box 8044 Seoul, South Korea.
* Present address: Korea Polar Research Institute, Incheon 406-840, South Korea.
‡To whom correspondence should be addressed.
† These authors contributed equally to this work.
Abstract
The symbiotic microbiota profoundly affect many aspects of host physiology; however, the molecular mechanisms underlying host-microbe cross-talk are largely unknown. Here, we show that the pyrroloquinoline quinone?dependent alcohol dehydrogenase (PQQ-ADH) activity of a commensal bacterium, Acetobacter pomorum, modulates insulin/insulin-like growth factor signaling (IIS) in Drosophila to regulate host homeostatic programs controlling developmental rate, body size, energy metabolism, and intestinal stem cell activity. Germ-free animals monoassociated with PQQ-ADH mutant bacteria displayed severe deregulation of developmental and metabolic homeostasis. Importantly, these defects were reversed by enhancing host IIS or by supplementing the diet with acetic acid, the metabolic product of PQQ-ADH.
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