한빛사 논문
Abstract
Hyun-Ji Parka, Fan Yangb, Seung-Woo Choa
a Department of Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea
b Department of Orthopaedic Surgery and Bioengineering, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Received 23 May 2011; Accepted 18 September 2011. Available online 24 September 2011.
Abstract
Genetic medicines that induce angiogenesis represent a promising strategy for the treatment of ischemic diseases. Many types of nonviral delivery systems have been tested as therapeutic angiogenesis agents. However, their delivery efficiency, and consequently therapeutic efficacy, remains to be further improved, as few of these technologies are being used in clinical applications. This article reviews the diverse nonviral gene delivery approaches that have been applied to the field of therapeutic angiogenesis, including plasmids, cationic polymers/lipids, scaffolds, and stem cells. This article also reviews clinical trials employing nonviral gene therapy and discusses the limitations of current technologies. Finally, this article proposes a future strategy to efficiently develop delivery vehicles that might be feasible for clinically relevant nonviral gene therapy, such as high-throughput screening of combinatorial libraries of biomaterials.
Keywords: Nonviral delivery; Genetic medicines; Ischemia; Therapeutic angiogenesis; High-throughput screening
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