한빛사 논문
Daishun Ling1,‡, Wooram Park2,‡, Yong Il Park1, Nohyun Lee1, Fangyuan Li2, Changyeong Song1, Prof. Su-Geun Yang4, Prof. Seung Hong Choi3, Prof. Kun Na2,*, Prof. Taeghwan Hyeon1,*
1World Class University (WCU) program of Chemical Convergence for Energy & Environment (C2E2) and, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (Korea)
2Department of Biotechnology, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743 (Korea)
3Diagnostic Radiology, Seoul National University Hospital, and, Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)
4Department of Applied Bioscience, CHA University, Seoul 135-081 (Korea)
Email: Prof. Kun Na, Prof. Taeghwan Hyeon
*Correspondence: Prof. Taeghwan Hyeon, World Class University (WCU) program of Chemical Convergence for Energy & Environment (C2E2) and, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (Korea)
*Correspondence: Prof. Kun Na, Department of Biotechnology, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743 (Korea)
Abstract
All bound up: A poly(L-3,4-dihydroxyphenylalanine)-based ligand converts hydrophobic nanoparticles into hydrophilic and biocompatible species through several binding modes. Nanoparticles functionalized with this ligand (see picture) are highly stable in various aqueous solutions. A successful in vivo MRI application using functionalized Fe3O4 nanoparticles confirmed their suitability for various biomedical applications.
Keywords:biocompatibility;contrast agents;coordination modes;nanoparticles;polymers
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