한빛사 논문
Abstract
In-Cheol Sun1, Dae-Kyung Eun2, Dr. Heebeom Koo1, Dr. Chang-Yong Ko3, Dr. Han-Sung Kim3, Dr. Dong Kee Yi4, Dr. Kuiwon Choi1, Dr. Ick Chan Kwon1, Dr. Kwangmeyung Kim1,*, Dr. Cheol-Hee Ahn2,*
1Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea)
2Research Institute of Advanced Materials (RIAM), Department of Materials Science and Engineering, Seoul National University, San 56-1, Sillim, Gwanak, Seoul, 151-744 (Korea)
3Department of Biomedical Engineering, Yonsei Univeristy, Wonju, Ganwondo 220-710 (Korea)
4Division of Bionanotechnology, Gachon Bionano Institute, Kyungwon University, Geonggi-do, 461-701 (Korea)
Email: Dr. Kwangmeyung Kim, Dr. Cheol-Hee Ahn
*Correspondence: Dr. Kwangmeyung Kim, Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea)
*Correspondence: Dr. Cheol-Hee Ahn, Research Institute of Advanced Materials (RIAM), Department of Materials Science and Engineering, Seoul National University, San 56-1, Sillim, Gwanak, Seoul, 151-744 (Korea)
†We thank the late Prof. Tae Gwan Park for valuable discussion about this research. This work was financially supported by the Real-Time Molecular Imaging Project, GRL Program of MEST, Intramural Research Program of KIST, M.D.-Ph.D. Program (2010-0019863, 2010-0019864), and the Basic Science Research Program (2010-0027955) of MEST.
Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits was developed. The excellent stability, tumor targeting ability, enhanced X-ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes.
Keywords:computed tomography;gold;imaging agents;nanoparticles
논문정보
관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
관련분야 논문보기
해당논문 저자보기