Pyong-Gon Moon1,2, Sungyong You3, Jeong-Eun Lee1,2, Daehee Hwang3, Moon-Chang Baek1,2,*
1Department of Molecular Medicine
2Cell and Matrix Biology Research Institute, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
3School of Interdisciplinary Bioscience and Bioengineering & Department of Chemical Eng., POSTECH, Pohang 790-784, Republic of Korea
*Correspondence: Moon-Chang Baek, Department of Molecular Medicine, School of Medicine, Kyungpook National University, 101 Dongin-dong 2 Ga, Jung-gu, Daegu 700-422, Republic of Korea.
A number of highly abundant proteins in urine have been identified through proteomics approaches, and some have been considered as disease-biomarker candidates. These molecules might be clinically useful in diagnosis of various diseases. However, none has proven to be specifically indicative of perturbations of cellular processes in cells associated with urogenital diseases. Exosomes could be released into urine which flows through the kidney, ureter, bladder and urethra, with a process of filtration and reabsorption. Urinary exosomes have been recently suggested as alternative materials that offer new opportunities to identify useful biomarkers, because these exosomes secreted from epithelial cells lining the urinary track might reflect the cellular processes associated with the pathogenesis of diseases in their donor cells. Proteomic analysis of such urinary exosomes assists the search of urinary biomarkers reflecting pathogenesis of various diseases and also helps understanding the function of urinary exosomes in urinary systems. Thus, it has been recently suggested that urinary exosomes are one of the most valuable targets for biomarker development and to understand pathophysiology of relevant diseases. ⓒ 2011 Wiley Periodicals, Inc. Mass Spec Rev
Keywords:urinary exosomes;urogenital diseases;biomarkers;proteomics