Prof. Hyeonseok Yoon1,2,‡, Dr. Jin-Ho Ahn1,‡, Dr. Paul W. Barone1, Dr. Kyungsuk Yum1, Richa Sharma1, Ardemis A. Boghossian1, Dr. Jae-Hee Han1, Prof. Michael S. Strano1
1Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA), Fax: (+1)617-253-8723
2Department of Polymer and Fiber System Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 500-757 (South Korea)
†This work was funded by the MIT Deshpande Center for Technological Innovation and a Beckman Young Investigator award for M.S.S.
‡These authors contributed equally to this work.
Glucose sensor: Glucose-binding protein (GBP) covalently conjugated to a fluorescent single-walled carbon nanotube (SWNT) is shown to act as an optical switch. Hinge-bending response to glucose causes a reversible exciton quenching of the SWNT fluorescence with high selectivity (see scheme).
Keywords:carbon nanotube;fluorescence;glucose;optical modulation;periplasmic binding protein