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조회 1603  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Abdominal Visceral Adipose Tissue Volume Is Associated With Increased Risk of Erosive Esophagitis in Men and Women

Su Youn Nam*, Il Ju Choi, Kum Hei Ryu*, Bum Joon Park*, Hyun Bum Kim§ and Byung-Ho Nam

Center for Gastric Cancer, National Cancer Center, Goyang, Korea
* Center for Cancer Prevention and Detection, National Cancer Center, Goyang, Korea
Center for Clinical Trials, National Cancer Center, Goyang, Korea
§ Department of Radiology, National Cancer Center, Goyang, Korea

Conflicts of interest The authors disclose no conflicts.

Funding Supported by a grant (NCC 0810200) from the National Cancer Center, Korea, which had a role in the collection of the questionnaires and was financially responsible for the abdominal multidetector computed tomography.

Background & Aims
Data on the association between erosive esophagitis and obesity are inconsistent because of variations in study populations and methods used to determine obesity.

Methods
Participants in a prospective health-screening cohort underwent esophagogastroduodenoscopy and computed tomography. The association between erosive esophagitis and obesity (measured by body mass index [BMI], waist circumference, and abdominal visceral adipose tissue volume) was estimated with odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for confounding factors. We also analyzed the association between obesity and erosive esophagitis by sex.

Results
The prevalence of erosive esophagitis was 9.3% (495/5329). The OR for erosive esophagitis correlated with obesity measured by BMI, waist circumference, and abdominal visceral adipose tissue volume (P < .001 for each factor). The multivariate OR for erosive esophagitis was 1.97 (95% CI: 1.34-2.90) for a visceral adipose tissue volume of 500?999 cm3, 2.27 (95% CI: 1.51-3.39) for 1000?1499 cm3, and 2.94 (95% CI: 1.87-4.62) for ≥1500 cm3, compared with participants who had visceral adipose tissue volumes less than 500 cm3. When measures of obesity were analyzed simultaneously, abdominal visceral adipose tissue volume, but not BMI or waist circumference, was associated with erosive esophagitis. The 3 measures of obesity were significantly associated with erosive esophagitis in males, but only visceral adipose tissue volume was associated with erosive esophagitis in females (P = .002).

Conclusions
In contrast to BMI or waist circumference, abdominal visceral adipose tissue volume is associated with an increased risk of erosive esophagitis in males and females.

Keywords: Gastroesophageal Reflux Disease, Reflux Esophagitis, Visceral Fat, Abdominal Obesity

Abbreviations used in this paper: BMI, body mass index, CI, confidence interval, CT, computed tomography, GERD, gastroesophageal reflux disease, MRI, magnetic resonance imaging, OR, odds ratio

논문정보
- 형식: Research article
- 게재일: 2010년 12월 (BRIC 등록일 2010-12-15)
- 연구진: 국내연구진태극기
- 분야: Medicine
세포 형광 이미징 멀티플렉싱을 위한 초고속 사이클링[Angew. Chem.-Int. Edit.]
고진아
발표: 고진아 (Massachusetts General Ho...)
일자: 2020년 4월 14일 (화) 오전 10시 (한국시간)
언어: 영어
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