Prof. Jaemoon Yang1,3, Jihye Choi2, Doyeon Bang2, Eunjung Kim2, Eun-Kyung Lim2, Huiyul Park4, Prof. Jin-Suck Suh1,3, Prof. Kyung-Hwa Yoo4, Prof. Eun-Kyung Kim2, Prof. Yong-Min Huh1,3, Prof. Seungjoo Haam2,3
Article first published online: 5 DEC 2010 DOI: 10.1002/anie.201005075
1Department of Radiology, Yonsei University, Seoul 120-752 (Republic of Korea)
2Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749 (Republic of Korea)
3YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752 (Republic of Korea)
4Department of Physics, Yonsei University, Seoul 120-749 (Republic of Korea)
†This research was supported by the KOSEF grant funded by MOST (No. M10755020001-07N5502-00110), the Korean Health Technology R&D Project, Ministry of Health, Welfare & Family Affairs (A101954), and the KRIBB Research Initiative Program.
Keywords:cancer;nanoparticles;near-infrared light;photothermal agents;polymers
Infiltrate and destroy: In an environment rich in protonating or oxidative species, such as the intracellular milieu of cancer cells, the main absorption band of spherical, water-soluble polyaniline nanoparticles was red-shifted to a near-infrared (NIR) wavelength as a result of the formation of the emeraldine salt (see picture). The doped nanoparticles caused photothermal ablation of cancer cells upon NIR laser irradiation in vitro and in vivo.