한빛사 논문
Abstract
Sun Ha Jee1, 2, 11, Jae Woong Sull3, 11, Jong-Eun Lee4, Chol Shin5, Jongkeun Park6, 7, Heejin Kimm1, Eun-Young Cho4, Eun-Soon Shin4, Ji Eun Yun1, Ji Wan Park8, Sang Yeun Kim1, Sun Ju Lee1, Eun Jung Jee1, Inkyung Baik9, Linda Kao2, Sungjoo Kim Yoon6, 7, Yangsoo Jang10, and Terri H. Beaty2
1 Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 102-752, South Korea
2 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
3 Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University, Seongnam 461-713, South Korea
4 DNA Link, Inc., Seoul 121-850, South Korea
5 Department of Internal Medicine, Korea University Ansan Hospital, Ansan 425-707, South Korea
6 Research Institute of Molecular Genetics, The Catholic University of Korea, Seoul 137-701, South Korea
7 Department of Biomedical Sciences, The Catholic University of Korea, Seoul 137-701, South Korea
8 Department of Medical Genetics, College of Medicine, Hallym University, Chuncheon 200-702, South Korea
9 Department of Foods and Nutrition, College of Natural Sciences, Kookmin University, Seoul 136-702, South Korea
10 Cardiology Division and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul 102-752, South Korea
Corresponding author
Corresponding author
11 These two authors equally contributed to this work
Abstract
Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in CDH13 on chromosome 16 (p = 1.69 ×10-15 in the initial sample, p = 6.58 ×10-39 in the second genome-wide sample, and p = 2.12 × 10-32 in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2.82 × 10-83. The association of rs3865188 with high-molecular-weight adiponectin (p = 7.36 × 10-58) was even stronger in the third sample. A reporter assay that evaluated the effects of a CDH13 promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold. This study clearly shows that genetic variants in CDH13 influence adiponectin levels in Korean adults.
논문정보
관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기