한빛사 논문
Abstract
Hongje Jang 1, Young-Kwan Kim 1, Hyun-Mi Kwon 2, Woon-Seok Yeo, Prof. Dr. 2, Dong-Eun Kim, Prof. Dr. 2, Dal-Hee Min, Prof. Dr. 1 *
1Department of Chemistry, Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701 (Korea), Fax: (+82)-42-350-2810
2Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701 (Korea)
*Correspondence to Dal-Hee Min, 1Department of Chemistry, Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701 (Korea), Fax: (+82)-42-350-2810
†This work was supported by the Basic Science Research Program and Mid-career Researcher Program through the National Research Foundation of Korea (NRF) funded by the Korean government (the Ministry of Education, Science, and Technology, MEST; grant nos. 313-2008-2-C00538, 2008-0062074, and 2009-0071058), by the Nano R&D program (2008-2004457) and WCU Project (R33-10128), and by the National Honor Scientist Program.
Funded by:
National Research Foundation of Korea (NRF)
Ministry of Education, Science, and Technology, MEST; Grant Number: 313-2008-2-C00538, 2008-0062074, 2009-0071058
Nano R&D program; Grant Number: 2008-2004457
WCU Project; Grant Number: R33-10128
National Honor Scientist Program
Keywords
biosensors, DNA, fluorescence spectroscopy, graphene, viruses
Abstract
Time to unwind: Graphene oxide (GO) enables the quantitative measurement of helicase-dependent double-stranded DNA (dsDNA) unwinding activity in real time. GO selectively binds to unwound fluorescent-dye-labeled single-stranded DNA and quenches its fluorescence (see picture). The helicase activity is monitored by following the change in fluorescence.
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