한빛사 논문
Abstract
Hyun-Woo Rhee, Dr. 1, Seung Hwan Lee 1, Ik-Soo Shin, Dr. 1, So Jung Choi 1, Hun Hee Park, Dr. 2, Kyungja Han, Prof. Dr. 2, Tai Hyun Park, Prof. Dr. 1 *, Jong-In Hong, Prof. Dr. 1 *
1Department of Chemistry, School of Chemical & Biological Engineering, Seoul National University, Seoul 151-747 (Korea), Fax: (+82) 2-889-1568
2Department of Clinical Pathology, Catholic University Medical College, Seoul (Korea)
*Correspondence to Tai Hyun Park, 1Department of Chemistry, School of Chemical & Biological Engineering, Seoul National University, Seoul 151-747 (Korea), Fax: (+82) 2-889-1568
*Correspondence to Jong-In Hong, 1Department of Chemistry, School of Chemical & Biological Engineering, Seoul National University, Seoul 151-747 (Korea), Fax: (+82) 2-889-1568
†This study was supported by a National Research Foundation (NRF) grant funded by the MEST (Grant Nos. 2009-0080734, 2009-0081997, 2010-0000825, WCU project R32-2009-000-10213-0). H.-W.R. is the recipient of POSCO T.J. Park postdoctoral fellowship. Gleevec was provided by Novartis.
Funded by:
MEST; Grant Number: 2009-0080734, 2009-0081997, 2010-0000825, WCU project R32-2009-000-10213-0
Keywords
cancer, fluorescence, fluorescent probes, kinases, phosphorylation
Abstract
Turn off the light! A kinase assay system employs fluorescent peptides and a phosphate-selective fluorescence quencher probe, and can be placed on a microfluidic chip (see picture). The system can be used for real-time kinase monitoring, kinase inhibitor screening, and cancer diagnosis based on abnormal kinase activity observed in patients samples.
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