한빛사 논문
Abstract
Daejong Jeon, Sangwoo Kim, Mattu Chetana, Daewoong Jo, H Earl Ruley, Shih-Yao Lin, Dania Rabah, Jean-Pierre Kinet & Hee-Sup Shin
Affiliations
Center for Neural Science, Korea Institute of Science and Technology, Seoul, Korea.
Daejong Jeon,Sangwoo Kim,Mattu Chetana &Hee-Sup Shin
Department of Neuroscience, University of Science and Technology, Daejeon, Korea.
Sangwoo Kim & Hee-Sup Shin
ProCell Therapeutics, ProCell R&D Center, Seoul, Korea.
Daewoong Jo
Department of Immunology and Microbiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
H Earl Ruley
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Shih-Yao Lin,Dania Rabah &Jean-Pierre Kinet
Present address: Department of Neurology, Seoul National University Hospital, Seoul, Korea.
Daejong Jeon
Contributions
D. Jeon and H.-S.S. designed the experiments. D. Jeon purified Cre protein. D. Jo and H.E.R. made and provided the vector containing His6-NLS-Cre-MTS. D. Jeon, S.K. and M.C. performed surgeries, microinjections and immunostainings and analyzed the data. D. Jeon and S.K. performed in vivo electrophysiology. S.-Y.L., D.R. and J.-P. K. generated the Cav1.2 conditional mice. D. Jeon and H.-S.S. wrote the manuscript. All of the authors commented on the manuscript.
Competing financial interests
The authors declare no competing financial interests.
Corresponding author
Correspondence to: Hee-Sup Shin
Abstract
Fear can be acquired vicariously through social observation of others suffering from aversive stimuli. We found that mice (observers) developed freezing behavior by observing other mice (demonstrators) receive repetitive foot shocks. Observers had higher fear responses when demonstrators were socially related to themselves, such as siblings or mating partners. Inactivation of anterior cingulate cortex (ACC) and parafascicular or mediodorsal thalamic nuclei, which comprise the medial pain system representing pain affection, substantially impaired this observational fear learning, whereas inactivation of sensory thalamic nuclei had no effect. The ACC neuronal activities were increased and synchronized with those of the lateral amygdala at theta rhythm frequency during this learning. Furthermore, an ACC-limited deletion of Cav1.2 Ca2+ channels in mice impaired observational fear learning and reduced behavioral pain responses. These results demonstrate the functional involvement of the affective pain system and Cav1.2 channels of the ACC in observational social fear.
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