한빛사 논문
Abstract
Dong-Hyun Kim1, Elena A. Rozhkova2, Ilya V. Ulasov3, Samuel D. Bader1,2, Tijana Rajh2, Maciej S. Lesniak3 & Valentyn Novosad1
Nanomagnetic materials offer exciting avenues for probing cell mechanics and activating mechanosensitive ion channels, as well as for advancing cancer therapies. Most experimental works so far have used superparamagnetic materials. This report describes a first approach based on interfacing cells with lithographically defined microdiscs that possess a spin-vortex ground state. When an alternating magnetic field is applied the microdisc vortices shift, creating an oscillation, which transmits a mechanical force to the cell. Because reduced sensitivity of cancer cells toward apoptosis leads to inappropriate cell survival and malignant progression, selective induction of apoptosis is of great importance for the anticancer therapeutic strategies. We show that the spin-vortex-mediated stimulus creates two dramatic effects: compromised integrity of the cellular membrane, and initiation of programmed cell death. A low-frequency field of a few tens of hertz applied for only ten minutes was sufficient to achieve ~90% cancer-cell destruction in vitro.
1.Materials Sciences Division, Argonne National Laboratory, Argonne, Illinois 60439, USA
2.Center for Nanoscale Materials, Argonne National Laboratory, Argonne, Illinois 60439, USA
3.The Brain Tumor Center, The University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA
Correspondence to: Elena A. Rozhkova2
Correspondence to: Valentyn Novosad1
논문정보
관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기