한빛사 논문
Abstract
Seogang Hyun,1 Youngseok Lee,1 Sung-Tae Hong,1 Sunhoe Bang,1 Donggi Paik,1 Jongkyun Kang,1 Jinwhan Shin,1 Jaejung Lee,1 Keunhye Jeon,1 Seungyoon Hwang,1 Eunkyung Bae,2 and Jaeseob Kim1,
1 Department of Biological Sciences, Korea Advanced Institute of Science & Technology, 373-1 Guseong-Dong, Yuseong-Gu, Daejeon 305-701, Korea
2 GenExel, Inc., Korea Advanced Institute of Science & Technology, 373-1 Guseong-Dong, Yuseong-Gu, Daejeon 305-701, Korea
Correspondence : Jaeseob Kim
Ph: 82 11 438 2632; Fax: 82 42 862 2504
The pigment-dispersing factor (PDF) is a neuropeptide controlling circadian behavioral rhythms in Drosophila, but its receptor is not yet known. From a large-scale temperature preference behavior screen in Drosophila, we isolated a P insertion mutant that preferred different temperatures during the day and night. This mutation, which we named han, reduced the transcript level of CG13758. We found that Han was expressed specifically in 13 pairs of circadian clock neurons in the adult brain. han null flies showed arrhythmic circadian behavior in constant darkness. The behavioral characteristics of han null mutants were similar to those of pdf null mutants. We also found that PDF binds specifically to S2 cells expressing Han, which results in the elevation of cAMP synthesis. Therefore, we herein propose that Han is a PDF receptor regulating circadian behavioral rhythm through coordination of activities of clock neurons.
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