한빛사 논문
Abstract
aInterdisciplinary Program of Integrated Biotechnology, Sogang University, #1 Shinsu-dong, Mapo-gu, Seoul 121-742, Republic of Korea
bCollege of Bionanotechnology, Kyungwon University, Bokjung-dong, Sujung-gu, Seongnam 461-701, Republic of Korea
cDepartment of Chemical and Biomolecular Engineering, Sogang University, #1 Shinsu-dong, Mapo-gu, Seoul 121-742, Republic of Korea
Received 12 September 2009; accepted 12 October 2009. Available online 25 October 2009.
Abstract
In this present study, a nanoscale protein-based memory device consisting of recombinant azurin with its cysteine residues modified by site-directed mutagenesis method has been developed. Cysteine residues were modified to directly coordinate with the gold surface without use of any chemical linkers. Cyclic voltammetry (CV) method was used to measure the redox behavior of the immobilized azurin. Open-circuit potential amperometry (OCPA) technique allowed observing the memory characteristics including “write”, “erase” and “read” functions of a nanoscale memory device. The variations in topology and the electron transfer properties, under the application of redox potentials, of the azurin adsorbed on Au was accomplished with electrochemical scanning tunneling microscopy. Data storage is achieved by applying redox potentials which are within the range of 500 mV. Finally the reliability of the proposed device has been examined. The key performance of the present system is it enables the memory working mechanism at nanoscale without degradation in performance and hence can be used as a nanoscale information storage device.
Keywords: Nanoscale memory; Recombinant azurin; Cyclic voltammetry; Open-circuit potential amperometry; Electrochemical scanning tunneling microscopy
*Corresponding author. Department of Chemical & Biomolecular Engineering, Interdisciplinary Program of Integrated Biotechnology, Sogang University, #1 Shinsu - dong, Mapo–Gu, Seoul 121–742, Republic of Korea. Tel.: +82 2 705 8480; fax: +82 2 3273 0331.
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