, Oscar Castanod, e
and Hae-Won Kima, b, e, *
aDepartment of Biomaterials Science, School of Dentistry, Dankook University, South Korea
bBiomaterials and Tissue Engineering Lab, Department of Nanobiomedical Science & WCU Research Center, Dankook University, South Korea
cDepartment of Biochemistry, Inha University College of Medicine, South Korea
dDepartment of Material Sciences and Metallurgical Engineering, Institute of Bioengineering of Catalonia (IBEC), Universitat Politècnica de Catalunya, Barcelona, Spain
eInstitute of Tissue Regeneration Engineering (ITREN), Dankook University, South Korea
Received 8 December 2008; accepted 16 July 2009. Available online 29 July 2009.
Nanofibrous materials produced by electrospinning processes have attracted considerable interest in tissue regeneration, including bone reconstruction. A range of novel materials and processing tools have been developed to mimic the native bone extracellular matrix for potential applications as tissue engineering scaffolds and ultimately to restore the degenerated functions of the bone. Degradable polymers, bioactive inorganics and their nanocomposites / hybrids nanofibers with suitable mechanical properties and bone bioactivity for osteoblasts and progenitor / stem cells have been produced. The surface functionalization with apatite minerals and proteins / peptides as well as drug encapsulation within the nanofibers is a promising strategy for achieving therapeutic functions with nanofibrous materials. Recent attempts to endow a 3D scaffolding technique to the electrospinning regime have shown some promise for engineering 3D tissue constructs. With the improvement in knowledge and techniques of bone-targeted nanofibrous matrices, bone tissue engineering is expected to be realized in the near future.
Keywords: Electrospun nanofiber; Bone tissue engineering; Biomimetic matrix; Bone bioactivity; 3D scaffolding
*Corresponding author. Department of Biomaterials Science, School of Dentistry, Dankook University, Shinbu, Cheonan, 330-714, South Korea. Tel./fax: +82 41 550 1926.