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조회 4256  인쇄하기 주소복사 트위터 공유 페이스북 공유 
BioWave  Vol. 17 No. 2 등록 2015.02.05 
DGIST Neurodegenerative diseases and Aging Lab.   이성배 교수
연구실 홈페이지
실험실 소개  

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The primary goal of our research is to reveal the cellular and molecular basis of neurodegenerative diseases. For this, we use disease model systems such as fruit flies (Drosophila Melanogaster) and mammalian cell culture.

Notably, many neurodegenerative diseases are often associated with obvious and specific neuronal abnormalities during early stage of the diseases that precede massive neuronal cell death.

But, our understanding on the molecular details and the clinical implications of these neuronal abnormalities is very limited since most of related researches focus primarily on the neuronal cell death observed in the late stage of the diseases that may not account for the early symptoms

So, our ongoing approach based on this unique research angle will provide invaluable clues to understanding these diseases and also will contribute to the future development of new and effective treatments.

the molecular details of neuronal maintenance and remodeling during aging of animals and their implication in neurodegenerative diseases

Our four major questions are:
1. What is the "cellular basis" of neurodegenerative diseases?
2. How can we ameliorate the toxicity of aggregated proteins associated with neurodegenerative diseases?
3. What's the relationship between neural cellular aging and late-onset neurodegenerative diseases?
4. What's the physiological consequence of altered cellular ion & mRNA homeostasis?
2006년 이후 대표논문

  • Park, J.*, Lee, S.B.*, Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.M., and Chung, J. (2006)
    Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin.
    Nature 441:1157-1161.(*:co-first author)

  • Lee, S.B.*, Kim, S.*, Lee, J., Park, J., Kim, J.M., and Chung, J. (2007)
    Atg1, an autophagy regulator, inhibits cell growth by negatively regulating p70 S6 kinase.
    EMBO reports. 8:360-365. (*:co-first author)

  • Lee, S.B.*, Kim,W.*, Lee,S.*, and Chung,J. (2007)
    Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.
    Biochem. Biophys. Res. Commun. 358(2):534-9. (*: co-first author)

  • Rumpf, S.*, Lee, S.B.*, Jan, L.Y., and Jan, Y.N. (2011)
    Neuronal remodelling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1.
    Development 138(6):1153-60 (*: co-first author)
  • Lee, S.B., Bagley, J.A., Lee, H.Y., Jan, L.Y., and Jan, Y.N. (2011)
    Polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila.
    Proc. Natl. Acad. Sci. 108(40):16795-16800

  • Fieni, F., Lee, S.B., Jan, Y.N., and Kirichok, Y. (2012)
    Activity of the Mitochondrial Ca2+ Uniporter Varies Greatly between Tissues.
    Nature Communications 3, 1317

  • Lee, S.B., Kang, H.S., and Kim, T. (2013)
    Nrg1 functions as a global transcriptional repressor of glucose-repressed genes through its direct binding to the specific promoter regions.
    Biochem. Biophys. Res. Commun. 439(4):501-505

  • Chung, C. G., and Lee, S. B. (2014)
    Regulation of Mitochondrial Calcium through the MCU complex.
    KSMCB Webzine

  • Kim, H.Y.*, Lee, S.B.*, Kang, H.S., Oh, G.T., and Kim, T. (2014)
    Two distinct domains of Flo8 activator mediates its role in transcriptional activation and the physical interaction with Mss11.
    Biochem. Biophys. Res. Commun. 449(2):202-207. (*: co-first author)

      지도교수 : 이성배 교수

       Ph.D. student : 정창근, 권민지, 박정향, 차인준
       M.S. student : 김규리, 조재호, 권정현
       Researcher : 전근혜

      Contact : 053-785-6122 (TEL) | Homepage
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