Dr Fan and colleagues evaluated our results of molecular genetic analysis of ARSA gene using their independent samples (Fan et al., 2020). They did not find the association between ARSA and Parkinson’s disease. In molecular genetic studies, it is not uncommon that the results vary with minor differences in ethnicity, sample size, or clinical diagnosis of the patients. We examined the effects of the N352S variant on Parkinson’s disease in 92 autosomal dominant Parkinson’s disease patients and 92 sporadic patients. We found that the N352S variant could be a protective factor in Parkinson’s disease. We realize that the number of samples was relatively small.