한빛사 논문
Ha Uk Chung 1,2,3,28, Alina Y. Rwei1,3,28, Aurélie Hourlier-Fargette 1,3,28, Shuai Xu1,3,4,28, KunHyuck Lee 1,3,5, Emma C. Dunne6, Zhaoqian Xie 7 , Claire Liu 1,3,8, Andrea Carlini1,3,5, Dong Hyun Kim3,9, Dennis Ryu3,10, Elena Kulikova10, Jingyue Cao10, Ian C. Odland3, Kelsey B. Fields3,5, Brad Hopkins6, Anthony Banks1,3, Christopher Ogle3, Dominic Grande3, Jun Bin Park3, Jongwon Kim 11,12, Masahiro Irie1,2,3, Hokyung Jang3,13, JooHee Lee10, Yerim Park14, Jungwoo Kim14, Han Heul Jo14, Hyoungjo Hahm9, Raudel Avila3,5,15,16, Yeshou Xu3,5,15,16,17, Myeong Namkoong1,8, Jean Won Kwak 1,3,15, Emily Suen18, Max A. Paulus19, Robin J. Kim3, Blake V. Parsons3, Kelia A. Human 8, Seung Sik Kim9, Manish Patel1,3,5,10,20, William Reuther 21, Hyun Soo Kim9,13, Sung Hoon Lee9, John D. Leedle10, Yeojeong Yun13, Sarah Rigali10, Taeyoung Son13, Inhwa Jung12, Hany Arafa1,3,8, Vinaya R. Soundararajan4, Ayelet Ollech4, Avani Shukla22, Allison Bradley6, Molly Schau23, Casey M. Rand6,24, Lauren E. Marsillio22,25, Zena L. Harris22,25, Yonggang Huang 3,5,15,16, Aaron Hamvas22,23,24, Amy S. Paller3,5,22, Debra E. Weese-Mayer 6,22,24,*, Jong Yoon Lee 1,3,9,10,* and John A. Rogers 1,3,5,8,13,15,26,27,*
1Simpson Querrey Institute, Northwestern University, Chicago, IL, USA.
2Department of Electrical and Computer Engineering, Northwestern University, Evanston, IL, USA.
3Center for Bio-integrated Electronics, Northwestern University, Evanston, IL, USA.
4Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
5Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.
6Division of Pediatric Autonomic Medicine, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA.
7State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian, China.
8Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
9Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
10Sibel Inc, Evanston, IL, USA.
11Photo-Electronic Hybrids Research Center, Korea Institute of Science and Technology (KIST), Seoul, South Korea.
12Department of Mechanical Engineering, Kyung Hee University, Yongin, Republic of Korea.
13Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
14Department of Computer Science, University of Illinois at UrbanaChampaign, Urbana, IL, USA.
15Department of Mechanical Engineering, Northwestern University, Evanston, IL, USA. 16Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL, USA.
17Key Laboratory of C&PC Structures of the Ministry of Education, Southeast University, Nanjing, China.
18Department of Neurobiology, Northwestern University, Evanston, IL, USA.
19Department of Biology, Northwestern University, Evanston, IL, USA.
20University of Illinois College of Medicine at Chicago, Chicago, IL, USA.
21Department of Graphic Design and Industrial Design at North Carolina State University, Raleigh, NC, USA.
22Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA.
23Division of Neonatology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA.
24Stanley Manne Children’s Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA.
25Division of Pediatric Critical Care Medicine, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA.
26Department of Chemistry, Northwestern University, Evanston, IL, USA.
27Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
28These authors contributed equally: Ha Uk Chung, Alina Y. Rwei, Aurélie Hourlier-Fargette, Shuai Xu.
*Corresponding author
Abstract
Standard clinical care in neonatal and pediatric intensive-care units (NICUs and PICUs, respectively) involves continuous monitoring of vital signs with hard-wired devices that adhere to the skin and, in certain instances, can involve catheter-based pressure sensors inserted into the arteries. These systems entail risks of causing iatrogenic skin injuries, complicating clinical care and impeding skin-to-skin contact between parent and child. Here we present a wireless, non-invasive technology that not only offers measurement equivalency to existing clinical standards for heart rate, respiration rate, temperature and blood oxygenation, but also provides a range of important additional features, as supported by data from pilot clinical studies in both the NICU and PICU. These new modalities include tracking movements and body orientation, quantifying the physiological benefits of skin-to-skin care, capturing acoustic signatures of cardiac activity, recording vocal biomarkers associated with tonality and temporal characteristics of crying and monitoring a reliable surrogate for systolic blood pressure. These platforms have the potential to substantially enhance the quality of neonatal and pediatric critical care.
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