한빛사 논문
Ju-Ha Kim1, Jisung Hwang1, Ji Hoon Jung1, Hyo-Jung Lee1, Dae Young Lee2 and Sung-Hoon Kim1,*
1 Cancer Molecular Target Herbal Research Lab, College of Korean Medicine, Kyung Hee university, 1 Hoegi-dong, Dongdaemun-gu, Seoul 02447, Republic of Korea.
2 Department of Herbal Crop Research, Rural Development Administration, National Institute of Horticultural and Herbal Science, Eumseong 27709, Republic of Korea.
* Correspondence : Sung-Hoon Kim
Abstract
Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg) cells and the dual roles of FOXP proteins as an oncogene or a tumor suppressor are unclear and controversial in cancers to date. Thus, the present review highlighted research history, dual roles of FOXP proteins as a tumor suppressor or an oncogene, their molecular networks with other proteins and noncoding RNAs, cellular immunotherapy targeting FOXP3, and clinical implications in cancer progression.
Keywords: FOXP proteins, Molecular networks, Noncoding RNAs, Cellular immunotherapy, Clinical implications and cancer progression
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