전희철(New York University) | 전전두 (prefrontal) - 내후각 (entorhinal) 신경세포들을 통한 항목 규칙 학습 [Nature] | 웨비나

학술웨비나 개최완료

전전두 (prefrontal) - 내후각 (entorhinal) 신경세포들을 통한 항목 규칙 학습 [Nature]

조회1289

2024년 10월 14일 (월) 오전 10시
전희철(New York University)

개요

							The ability to learn novel items depends on brain functions that store information about items classified by their associated meanings and outcomes, but the underlying neural circuit mechanisms of this process remain poorly understood. Here we show that deep layers of the lateral entorhinal cortex (LEC) contain two groups of ‘item–outcome neurons’: one developing activity for rewarded items during learning, and another for punished items. As mice learned an olfactory item–outcome association, we found that the neuronal population of LEC layers 5/6 (LECL5/6) formed an internal map of pre-learned and novel items, classified into dichotomic rewarded versus punished groups. Neurons in the medial prefrontal cortex (mPFC), which form a bidirectional loop circuit with LECL5/6, developed an equivalent item–outcome rule map during learning. When LECL5/6 neurons were optogenetically inhibited, tangled mPFC representations of novel items failed to split into rewarded versus punished groups, impairing new learning by mice. Conversely, when mPFC neurons were inhibited, LECL5/6 representations of individual items were held completely separate, disrupting both learning and retrieval of associations. These results suggest that LECL5/6 neurons and mPFC neurons co-dependently encode item memory as a map of associated outcome rules.