한빛사337건

• • 현상엽(아주대학교)

  • 한영민(서울대학교 의과대학, 서울대학교병원)

  • 문재윤(아주대학교)

  • 장진영(서울대학교 의과대학, 서울대학교병원)

  • 박대찬(아주대학교)

  [LETTER] Defining and tracing subtypes of patient-derived xenograft models in pancreatic ductal adenocarcinoma

  • Cancer Commun. Aug 2024, 44 (8) | https://doi.org/10.1002/cac2.12585

  • 2024.08
  • 의약학

• • Fakhar Ud Din(한양대학교 약학대학)

  • 김정석(한양대학교 약학대학)

  • 최한곤(한양대학교 약학대학)

  Injectable dual thermoreversible hydrogel for sustained intramuscular drug delivery

  • J. Control. Release Aug 30 2024, 374 S0168-3659(24)00584-4 | https://doi.org/10.1016/j.jconrel.2024.08.034

  • 2024.08

• • 이장순(University of Hawai'I Cancer Center)

  • 임석아(서울대학교 의과대학)

  The DNA repair pathway as a therapeutic target to synergize with trastuzumab deruxtecan in HER2-targeted antibody-drug conjugate-resistant HER2-overex

  • J. Exp. Clin. Cancer Res. Aug 21 2024, 43 (1) 236 | https://doi.org/10.1186/s13046-024-03143-3

  • 2024.08

• • 조유나(부산대학교 의과대학)

    Interview

  • 홍창완(부산대학교 의과대학)

  Targeting ROS-sensing Nrf2 potentiates anti-tumor immunity of intratumoral CD8+ T and CAR-T cells

  • Mol. Ther. August 21, 2024 | https://doi.org/10.1016/j.ymthe.2024.08.019

  • 2024.08
  • 의약학

• • 정영훈(인하대학교)

  • 이윤지(인하대학교)

  • 이상배(전북대학교)

  • 홍순선(인하대학교 의과대학)

  • 김경진(인하대학교)

  KCTD17-mediated Ras stabilization promotes hepatocellular carcinoma progression

  • Clin. Mol. Hepatol. Aug 05 2024, | https://doi.org/10.3350/cmh.2024.0364

  • 2024.08
  • 의약학

• • 이율(Washington State University)

  Redox-active vitamin C suppresses human osteosarcoma growth by triggering intracellular ROS-iron-calcium signaling crosstalk and mitochondrial dysfunc

  • Redox Biol. Jul 26 2024, 75 S2213-2317(24)00266-0 | https://doi.org/10.1016/j.redox.2024.103288

  • 2024.07

• • Thoa Thi Kim Nguyen(성균관대학교)

  • 우선민(계명대학교 의과대학)

  • 권택규(계명대학교 의과대학)

  • 육심명(성균관대학교)

  Enhanced anticancer efficacy of TRAIL-conjugated and odanacatib-loaded PLGA nanoparticles in TRAIL resistant cancer

  • Biomaterials Jul 30 2024, 312 S0142-9612(24)00267-9 | https://doi.org/10.1016/j.biomaterials.2024.122733

  • 2024.07
  • 의약학

• • 박주형(Stanford University)

    Interview

  SMYD5 methylation of rpL40 links ribosomal output to gastric cancer

  • Nature 24 July 2024 | https://doi.org/10.1038/s41586-024-07718-0

  • 2024.07
  • 생명과학

• • 신준혜(서강대학교, 피토맵)

    Interview

  • 윤혜원(서울대학교병원)

  • 김성룡(서강대학교, 피토맵)

  Enhanced efficacy of glycoengineered rice cell-produced trastuzumab

  • Plant Biotechnol. J. Jul 17 2024, | https://doi.org/10.1111/pbi.14429

  • 2024.07
  • 의약학

• • 박병선(한국과학기술연구원)

  • 김택훈(한국과학기술연구원)

  Polyamine and EIF5A hypusination downstream of c-Myc confers targeted therapy resistance in BRAF mutant melanoma

  • Mol. Cancer Jul 04 2024, 23 (1) | https://doi.org/10.1186/s12943-024-02031-w

  • 2024.07
  • 생명과학

• • 김하린(서울대학교, Stanford University)

  • 박성진(서울대학교)

  • 변영로(서울대학교)

  Stimulating macropinocytosis of peptide-drug conjugates through DNA-dependent protein kinase inhibition for treating KRAS-mutant cancer

  • J. Control. Release Jun 20 2024, 372 S0168-3659(24)00376-6 | https://doi.org/10.1016/j.jconrel.2024.06.028

  • 2024.06
  • 생명과학

• • 이대훈(경희대학교 약학대학, 큐리진)

  • 최진우(경희대학교 약학대학)

  Intravesical instillation-based mTOR-STAT3 dual targeting for bladder cancer treatment

  • J. Exp. Clin. Cancer Res. Jun 18 2024, 43 (1) | https://doi.org/10.1186/s13046-024-03088-7

  • 2024.06

• • Ramesh Duwa(성균관대학교)

  • 박소연(계명대학교)

  • 정지헌(성균관대학교 의과대학)

  • 육심명(성균관대학교 약학대학)

  Strengthened binding affinity of bispecific antibody nanoplatforms improved the anti-tumor efficacy

  • Chem. Eng. J. Available online 13 June 2024 | https://doi.org/10.1016/j.cej.2024.153128

  • 2024.06
  • 의약학

• • 심재혁(University of Massachusetts Chan Medical School)

  Engineering a targeted and safe bone anabolic gene therapy to treat osteoporosis in alveolar bone loss

  • Mol. Ther. Jun 26 2024, S1525-0016(24)00426-X | https://doi.org/10.1016/j.ymthe.2024.06.036

  • 2024.06
  • 의약학

• • 권민철(Janssen R&D)

  Preclinical efficacy of potent and selective menin-KMT2A inhibitor JNJ-75276617 in KMT2A- and NPM1-altered leukemias

  • Blood Jun 21 2024, blood.2023022480 | https://doi.org/10.1182/blood.2023022480

  • 2024.06

• • 오준용(UNIST)

  • Batakrishna Jana(UNIST)

  • 성준모(UNIST)

  • 곽상규(고려대학교)

  • 라명수(UNIST)

  • 유자형(UNIST)

  Unveiling the Power of Cloaking Metal-Organic Framework Platforms via Supramolecular Antibody Conjugation

  • ACS Nano Jun 07 2024, | https://doi.org/10.1021/acsnano.4c02624

  • 2024.06
  • 바이오·의료융합

• • 백세움(연세대학교 의과대학)

    Interview

  • 하현수(연세대학교 의과대학)

  • 박정수(연세대학교 의과대학)

  • 한대훈(연세대학교 의과대학)

  • 성학준(연세대학교 의과대학)

  Chip collection of hepatocellular carcinoma based on O2 heterogeneity from patient tissue

  • Nat. Commun. Jun 15 2024, 15 (1) | https://doi.org/10.1038/s41467-024-49386-8

  • 2024.06
  • 의약학

• • 권진(Duke University School of Medicine)

  Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig

  • Sci. Transl. Med. Jun 12 2024, 16 (751) | https://doi.org/10.1126/scitranslmed.adk6152

  • 2024.06
  • 의약학
• 

  임산해

  KAIST

  본 논문은 유전자 교정 도구인 CRISPR/Cas9 system의 ribonucleoprotein (RNP)를 lipid nanoparticle (LNP)에 탑재하여 효과적인 세포 및 암 조직으로의 전달에 대한 연구입니다. CRISPR/Cas9을 전달하는 형태에는 크게 plasmid, mRNA, RNP 3가지로 나눠질 수 있는데, 이중 RNP가 off-target effect가 가장 적어 실제 유전자 치료에 적합한 형태입니다.

  • J. Nanobiotechnol.
  • 2024.06.12

• • 황인영(National University of Singapore)

  • 장욱(National University of Singapore)

  Prodrug-conjugated tumor-seeking commensals for targeted cancer therapy

  • Nat. Commun. 21 May 2024 | https://doi.org/10.1038/s41467-024-48661-y

  • 2024.05