한빛사59건

• • 정금재(부경대학교)

  • Fazlurrahman Khan(부경대학교)

  • 김영목(부경대학교)

  Strategies for controlling polymicrobial biofilms: a focus on antibiofilm agents

  • Int. J. Antimicrob. Agents Jun 20 2024, S0924-8579(24)00161-4 | https://doi.org/10.1016/j.ijantimicag.2024.107243

  • 2024.06
  • 생명과학

• • 정소영(University of Wisconsin-Madison)

  Debottlenecking the DOPA 4,5-dioxygenase step with enhanced tyrosine supply boosts betalain production in Nicotiana benthamiana

  • Plant Physiol. Mar 18 2024, kiae166 | https://doi.org/10.1093/plphys/kiae166

  • 2024.03
  • 생명과학

• • 문태석(Washington University in St. Louis)

  Advances in ligand-specific biosensing for structurally similar molecules

  • Cell Syst. Dec 20 2023, 14 (12) S2405-4712(23)00301-0 | https://doi.org/10.1016/j.cels.2023.10.009

  • 2023.12
  • 생명과학

• • 이상엽(KAIST)

  A synthetic cell-free 36-enzyme reaction system for vitamin B12 production.

  • Nat. Commun. Aug 24 2023, 14 (1) 5177 | https://doi.org/10.1038/s41467-023-40932-4

  • 2023.08
  • 생명과학

• • 정금재(부경대학교)

  • Fazlurrahman Khan(부경대학교)

  • 김영목(부경대학교)

  Controlling biofilm and virulence properties of Gram-positive bacteria by targeting wall teichoic acid and lipoteichoic acid

  • Int. J. Antimicrob. Agents 2023 Aug 1;106941 | https://doi.org/10.1016/j.ijantimicag.2023.106941

  • 2023.08

• • 양재성(Centre for research in agricultural Genomics (CRAG))

  Challenges and advances towards the rational design of microalgal synthetic promoters in Chlamydomonas reinhardtii

  • J. Exp. Bot. 2023 Apr 7;erad100 | https://doi.org/10.1093/jxb/erad100

  • 2023.04
  • 생명과학

• • Charles Jo(Boston University)

  Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability

  • Mater. Today Bio Volume 19, April 2023, 100560 | https://doi.org/10.1016/j.mtbio.2023.100560

  • 2023.04

• • 김훈(University of Wisconsin-Madison, 현 USDA Forest Products Laboratory )

  Biomimetic oxidative copolymerization of hydroxystilbenes and monolignols

  • Sci. Adv. 2023 Mar 10;9(10):eade5519 | https://doi.org/10.1126/sciadv.ade5519

  • 2023.03
  • 생명과학

• • Fazlurrahman Khan(부경대학교)

  • 김영목(부경대학교)

  Multiple potential strategies for the application of nisin and derivatives

  • Crit. Rev. Microbiol. 2022 Aug 23;1-30. | https://doi.org/10.1080/1040841X.2022.2112650

  • 2022.08

• • 손소희(한국화학연구원, POSTECH)

  • 손창윤(POSTECH)

  • 오승수(POSTECH)

  • 이주영(한국화학연구원)

  Chain flexibility of medicinal lipids determines their selective partitioning into lipid droplets

  • Nat. Commun. Published 24 June 2022 | https://doi.org/10.1038/s41467-022-31400-6

  • 2022.06
  • 생명과학

• • 금형섭(KAIST)

  • 전상용(KAIST)

  Photomedicine based on heme-derived compounds

  • Adv. Drug Deliv. Rev. Volume 182, March 2022, 114134 | https://doi.org/10.1016/j.addr.2022.114134

  • 2022.03
  • 바이오·의료융합

• • 이호진(서울대학교)

  • 민혜영(서울대학교)

  • 이호영(서울대학교)

  A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects

  • Theranostics Published 2022-1-1, 12(1):105-125 | doi:10.7150/thno.63788

  • 2022.01
  • 생명과학

• • 배지윤(KAIST)

  • 조병관(KAIST)

  Valorization of C1 gases to value-added chemicals using acetogenic biocatalysts

  • Chem. Eng. J. Available online 15 July 2021, Volume 428, 131325 | https://doi.org/10.1016/j.cej.2021.131325

  • 2021.07
  • 생명과학

• • Vinit Raj(영남대학교)

  • 이진태(영남대학교)

  2H/4H-Chromenes-A Versatile Biologically Attractive Scaffold

  • Front. Chem. 2020 Aug 5;8:623 | https://doi.org/10.3389/fchem.2020.00623

  • 2020.08
  • 생명과학

• • Rongjia Shi(중앙대학교)

  • Shuaihui Feng(중앙대학교)

  • 박찬영(중앙대학교)

    Interview

  • 박태정(중앙대학교 화학과)

  Fluorescence detection of histamine based on specific binding bioreceptors and carbon quantum dots

  • Biosens. Bioelectron. Available online 14 August 2020, 112519 | https://doi.org/10.1016/j.bios.2020.112519

  • 2020.08
  • 바이오·의료융합
• 

  김영훈

  Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research

  1. 논문관련 분야의 소개, 동향, 전망을 설명, 연구과정에서 생긴 에피소드 본 논문 “The chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants”, we present the discovery of the first plant halogenase (dechloroacutumine halogenase; DAH). Halogenated natural compounds like vancomycin, chloramphenicol (antibiotics), etc. are of huge medicinal interest, and it turns out, they are relatively rare in plants. Plants, as sessile organisms, are excellent chemists and can catalyzing interesting, highly efficient chemical reactions. In this case, Moonseed vines can perform site-selective halogenation in the biosynthesis of an unusual tetracyclic chloroalkaloid, acutumine, which is a potential anti-leukemia drug. The discovery of DAH not only elucidates the terminal chlorination step of acutumine biosynthesis but also provides opportunities to think about how we can engineer plant systems to derivatize already-potent plant natural compounds for producing drugs with new bioactivities. For more information and news press by Whitehead Institute: http://wi.mit.edu/news/archive/2020/harnessing-moonseed-plant-s-chemical-know-how . 연구과정에서 생긴 에피소드: 3 months after joining Jing-Ke Weng’s lab at the Whitehead Institute, one of the postdocs, Andrew Mitchell, in our lab approached me with a potential project I could pursue-he had insights on Fe(II)-2OG-dependent halogenases, and I still remember sitting down with him and discussing how this could lead to an impactful discovery. I am extremely thankful for his mentorship! 2. 연구를 진행했던 소속기관 또는 연구소에 대해 소개 부탁 드립니다. 저는 Massachusetts Institute of Technology/Whitehead Institute, Jing-Ke Weng 교수님 연구실에서 Biological Engineering 박사 과정 공부를 하고있습니다. The Weng Lab investigates the origin and evolution of plant specialized metabolism at enzyme, pathway, and systems lev

  • Nat. Commun.
  • 2020.05.06

• • 김서형(Max Plank Institute of Molecular Plant Physiology)

  Growth of E. coli on formate and methanol via the reductive glycine pathway

  • Nat. Chem. Biol. Published10 February 2020 | DOI https://doi.org/10.1038/s41589-020-0473-5

  • 2020.02

• • 박민희(경북대학교 의과대학)

  • 진희경(경북대학교 수의과대학)

  • 배재성(경북대학교 의과대학)

  • 임미희(한국과학기술원 (KAIST))

  N,N′-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice

  • Proc. Natl. Acad. Sci. USA First published November 4, 2019 | https://doi.org/10.1073/pnas.1916318116

  • 2019.11
  • 생명과학

• • 최윤규(POSTECH)

  • 장영태(POSTECH, 기초과학연구원)

  Holding-Oriented versus Gating-Oriented Live-Cell Distinction: Highlighting the Role of Transporters in Cell Imaging Probe Development

  • Acc. Chem. Res. Publication Date:July 2, 2019 | https://doi.org/10.1021/acs.accounts.9b00253

  • 2019.07
  • 바이오·의료융합

• • 강정아(광주과학기술원)

  • 김송원(광주과학기술원)

  • 조유리(차의과학대학교, 강남차병원)

  • 진미선(광주과학기술원)

  • 박성규(광주과학기술원)

  Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly

  • Nat. Commun. Published: 16 May 2019, 10, Article number: 2184 | https://doi.org/10.1038/s41467-019-10200-5

  • 2019.05
  • 생명과학