한빛사490건

• • 정회성(NIDDK / National Institutes of Health)

  Single-Molecule Characterization of Heterogeneous Oligomer Formation during Co-Aggregation of 40- and 42-Residue Amyloid-β

  • J. Am. Chem. Soc. Sep 04 2024, 146 (35) | https://doi.org/10.1021/jacs.4c06372

  • 2024.09
  • 생명과학

• • 나윤영(POSTECH)

  • 김원종(POSTECH)

  Tailored small molecule for inflammation treatment: Dual scavenger targeting nitric oxide and reactive oxygen species

  • J. Control. Release Aug 29 2024, 374 S0168-3659(24)00573-X | https://doi.org/10.1016/j.jconrel.2024.08.026

  • 2024.08
  • 바이오·의료융합

• • 김경란(한국과학기술연구원)

  • 강지희(가천대학교 약학대학)

  • 고영탁(가천대학교 약학대학)

  • 안대로(한국과학기술연구원, UST)

  Systemic Brain Delivery of Oligonucleotide Therapeutics Enhanced by Protein Corona-Assisted DNA Cubes

  • Small Methods Aug 02 2024, | https://doi.org/10.1002/smtd.202400902

  • 2024.08
  • 의약학

• • 한희선(University of Illinois at Urbana-Champaign)

  Drop-by-Drop Addition of Reagents to a Double Emulsion

  • Small Aug 05 2024, | https://doi.org/10.1002/smll.202404121

  • 2024.08

• • 윤상호(Texas A&M University)

  Capturing RAS oligomerization on a membrane

  • Proc. Natl. Acad. Sci. USA 2024 Aug 20;121(34):e2405986121 | https://doi.org/10.1073/pnas.2405986121

  • 2024.08

• • Yan Liu(성균관대학교)

  • 조재열(성균관대학교)

  Oral Piwi-Interacting RNA Delivery Mediated by Green Tea-Derived Exosome-Like Nanovesicles for the Treatment of Aortic Dissection

  • Adv. Healthc. Mater. Aug 01 2024, | https://doi.org/10.1002/adhm.202401466

  • 2024.08
  • 생명과학

• • 서유리(충남대학교 분석과학기술대학원)

  • 장예진(한국화학연구원)

  • 이선경(기초과학연구원, 현 카스큐어 테라퓨틱스)

  • 김미현(한국화학연구원)

  • 이주용(충남대학교 분석과학기술대학원)

  • 명경재(기초과학연구원)

  A dual inhibitor of PIP5K1C and PIKfyve prevents SARS-CoV-2 entry into cells

  • Exp. Mol. Med. 01 August 2024 | https://doi.org/10.1038/s12276-024-01283-2

  • 2024.08
• 

  성예원

  NIH

  We study cisplatin, which is a widely used and effective anticancer drug, but it has significant side effects, including ototoxicity (hearing loss) and nephrotoxicity (kidney injury), in pediatric and adult cancer patients. In this paper, we investigated the role of macrophages in cisplatin-induced hearing loss and kidney injury in mice.

  • Sci. Adv.
  • 2024.08.21

• • 이형민(University of North Carolina at Chapel Hill, 현 Medical University of South Carolina)

  Ube3a unsilencer for the potential treatment of Angelman syndrome

  • Nat. Commun. Jul 08 2024, 15 (1) 5558 | https://doi.org/10.1038/s41467-024-49788-8

  • 2024.07
  • 생명과학

• • 이경주(건국대학교)

  • 이윤미(건국대학교)

  • 임지홍(건국대학교)

  • 박주호(건국대학교)

  A novel chemically engineered multifunctional statin conjugate as self-assembled nanoparticles inhibiting bile acid transporters

  • J. Control. Release Jul 04 2024, S0168-3659(24)00439-5 | https://doi.org/10.1016/j.jconrel.2024.07.008

  • 2024.07
  • 바이오·의료융합

• • 나현지(고려대학교)

    Interview

  • 김종승(고려대학교)

  Bifunctional black phosphorus quantum dots platform: Delivery and remarkable immunotherapy enhancement of STING agonist

  • Biomaterials Jul 02 2024, 311 S0142-9612(24)00230-8 | https://doi.org/10.1016/j.biomaterials.2024.122696

  • 2024.07

• • 안주성(고려대학교)

  • 임종현(성균관대학교)

  • 이진용(성균관대학교)

  • 김종승(고려대학교)

  Lutetium Texaphyrin-Celecoxib Conjugate as a Potential Immuno-Photodynamic Therapy Agent

  • J. Am. Chem. Soc. Jul 03 2024, | https://doi.org/10.1021/jacs.4c05978

  • 2024.07
  • 바이오·의료융합

• • 이수현(유빅스테라퓨틱스, 연세대학교)

  • 김화연(연세대학교)

  • 노재석(연세대학교)

  • 송재환(연세대학교)

  • 이송희(유빅스테라퓨틱스)

  UBX-390: A Novel Androgen Receptor Degrader for Therapeutic Intervention in Prostate Cancer

  • Adv. Sci. Jul 03 2024, | https://doi.org/10.1002/advs.202400398

  • 2024.07
  • 생명과학

• • 김태영(연세대학교)

  • 최정원(UNIST, 현 Harvard University)

  • 박태은(UNIST)

  • 서정목(연세대학교)

  Lubricant-Coated Organ-on-a-Chip for Enhanced Precision in Preclinical Drug Testing

  • Small Jun 27 2024, | https://doi.org/10.1002/smll.202402431

  • 2024.06
  • 바이오·의료융합

• • 박기성(고려대학교)

  • 차한빛(고려대학교)

  • 이진협(고려대학교)

  • 백승필(고려대학교)

  DNA-controlled protein fluorescence: Design of aptamer-split peptide hetero-modulator for GFP to respond to intracellular ATP levels

  • Nucleic Acids Res. Jun 25 2024, gkae532 | https://doi.org/10.1093/nar/gkae532

  • 2024.06
  • 생명과학

• • 김형식(Harvard Medical School)

  A non-lipid nucleic acid delivery vector with dendritic cell tropism and stimulation

  • Theranostics 2024.05.05; 14(7): 2934-2945 | https://www.thno.org/v14p2934

  • 2024.05
  • 바이오·의료융합

• • 김지훈(성균관대학교)

  • 장수진(한국파스퇴르연구소)

  • 이원식(성균관대학교)

  Reducing Peptidoglycan Crosslinking by Chemical Modulator Reverts ?-lactam Resistance in Methicillin-Resistant Staphylococcus aureus

  • Adv. Sci. 15 May 2024 | https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202400858

  • 2024.05
  • 생명과학
• 

  명유찬

  The University of Queensland

  최근 신약 개발 동향을 살펴보면, 대형 제약회사의 전임상 연구 중 Pharmacokinetics (PK) 와 독성 평가단계에서 가장 많은 약물 후보물질들이 리스트에서 제외된다고 합니다. 결국, 후보물질 스크리닝 단계에서 물질의 효능만을 살펴보는 것이 아니라 PK 및 독성 예측값을 사용하여 후보 물질의 개발성 (developability)을 전반적으로 평가하는 것이 신약 개발 성공률을 높이는 방법이 될 것입니다.

  • Nucleic Acids Res.
  • 2024.05.07

• • 명유찬(The University of Queensland)

    Interview

  Deep-PK: deep learning for small molecule pharmacokinetic and toxicity prediction

  • Nucleic Acids Res. Apr 18 2024, gkae254 | https://doi.org/10.1093/nar/gkae254

  • 2024.04

• • 서영아(University of Michigan)

  Minimizing higher-order aggregation maximizes iron mobilization by small molecules

  • Nat. Chem. Biol. Apr 25 2024, | https://doi.org/10.1038/s41589-024-01596-3

  • 2024.04
  • 생명과학