place cell > 통합검색 | BRIC

통합검색

한빛사

내가 찾은 검색어

1place cell

'place cell' 에 대한 통합검색결과 90건입니다.

한빛사90건

최신순
관련도순

나타니엘 카르페나

단국대학교

Our research aimed to address a long-standing challenge in hearing loss therapy: how to generate functional cochlear hair cells in the lab. These cells are responsible for converting sound vibrations into electrical signals that the brain can interpret. In humans, once these cells are damaged-due to aging, noise, or drugs-they do not regenerate.
- Theranostics
- 2025.04.28
Sana Abdul Khaliq

가천대학교 의과대학

In this study, we investigated how a protein called ARHGEF3 regulates fat cell (adipocyte) development and enlargement?two key processes involved in obesity. We discovered that ARHGEF3 plays a dual role: it helps fat cells grow in size through the YAP-RhoA signaling pathway, and it promotes their full differentiation by boosting the activity of PPARγ, a master regulator of fat cell development.
- J. Adv. Res.
- 2025.04.26
- 허우녕(Duke University School of Medicine, 현 The Rockefeller University & Memorial Sloan Kettering Cancer Center)
  Interview
Topological interactions drive the first fate decision in the Drosophila embryo
- Nat. Phys. 25 February 2025 | https://doi.org/10.1038/s41567-025-02796-x
- 2025.02
- 생명과학
- 류근우(Memorial Sloan Kettering Cancer Center)
Cellular ATP demand creates metabolically distinct subpopulations of mitochondria
- Nature 06 November 2024 | https://doi.org/10.1038/s41586-024-08146-w
- 2024.11
- 안태양(University of California, San Diego)
Protocells by spontaneous reaction of cysteine with short-chain thioesters
- Nat. Chem. 30 October 2024 | https://doi.org/10.1038/s41557-024-01666-y
- 2024.10
Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer‘s disease
- Mol. Neurodegener. Jul 23 2024, 19 (1) | https://doi.org/10.1186/s13024-024-00740-w
- 2024.07
- 생명과학
- 최재혁(Northwestern University)
  Interview
Interferon subverts an AHR?JUN axis to promote CXCL13+ T cells in lupus
- Nature 10 July 2024 | https://doi.org/10.1038/s41586-024-07627-2
- 2024.07
- 박정현(National Cancer Institute, NIH)
Pathways and mechanisms of CD4+CD8αα+ intraepithelial T cell development
- Trends Immunol. Available online 20 March 2024 | https://doi.org/10.1016/j.it.2024.02.006
- 2024.03
- 생명과학
Integrative Magneto-Microfluidic Separation of Immune Cells Facilitates Clinical Functional Assays
- Small 2023 Jun 27;e2302809 | https://doi.org/10.1002/smll.202302809
- 2023.06
- 바이오·의료융합
- 박정현(National Cancer Institute, NIH)
Markers and makers of NKT17 cells
- Exp. Mol. Med. Published: 01 June 2023 | https://doi.org/10.1038/s12276-023-01015-y
- 2023.06
- 생명과학
- 김상훈(University of Pennsylvania)
Global remapping in granule cells and mossy cells of the mouse dentate gyrus
- Cell Reports Volume 42, Issue 4, 25 April 2023, 112334 | https://doi.org/10.1016/j.celrep.2023.112334
- 2023.04
- 바이오·의료융합
신요섭

서울대학교

1. 논문관련 분야의 소개, 동향, 전망을 설명, 연구과정에서 생긴 에피소드 해마는 학습과 기억에 중요한 영역이라는 것으로 잘 알려져 있습니다. 특히 해마에는 특정 장소에서만 선택적으로 활동을 하는 place cell (장소 세포)가 관찰되어 왔는데요, 이러한 장소 세포 활동의 의미를 이해하기 위해 많은 연구가 진행되어 왔지만, 이들의 활동이 어떤 의미가 있는지 명확하지 않은 상태로 남아있었어요. 장소세포는 다양한 감각자극들뿐만 아니라, 가치정보, 움직임 정보까지 모두 반영하여 활동한다고 알려져 있어요. 다양한 감각자극들이 있는 환경에서 돌아다니는 동물은 어디서 무엇을 보는지 알 수 없는 상황에서 해마의 활동을 해석하는 것은 쉽지 않았어요. 저희는 시각 자극을 자유롭게 조작할 수 있는 가상현실 (VR) 시스템을 구축하여, 시각 자극의 정량적 변화에 따른 장소세포의 활동을 측정했어요. 시각 자극의 다양한 조작을 통해서 이들의 활동이 환경의 변화를 어떻게 구분하고 기존의 기억을 유지함과 동시에 새로운 기억으로써 표상할 것인지에 대한 힌트를 얻을 수 있었습니다. 인지신경과학은 융합학문인 만큼 앞으로 동일한 실험 디자인을 이용해서 molecular level, system level, clinical level으로부터 얻은 결과를 다양한 관점에서 보고, 이를 하나로 모으는 과정이 필요하다고 생각합니다. 2. 연구를 진행했던 소속기관 또는 연구소에 대해 소개 부탁드립니다. 우리 연구실은 서울대학교 자연과학대학 뇌인지과학과 소속이에요. 연구실에는 다양한 배경의 사람들이 모여 연구하고 있습니다. 생물과학, 심리학, 언어학, 물리학, 전기공학, 피아노 전공, 체육교육 전공 등등…. 언제든 특정 주제에 대해 다양한 관점에서 이야기를 할 수 있는 기회가 있다는 점이 우리 연구실의 큰 강점 중 하나인 것 같습니다. 3. 연구 활동 하시면서 평소 느끼신 점 또는 자부심, 보람 평소에 궁금했던 것들에 대한 답을 어떻게 찾을 수 있을 것인지 구체화를 하고 이를 현실화하며 결과를 상상하는 과정이 즐거운 것 같아요. 특히, 이러한 과정을 통해 상상했던 결과를 확인할 때의 그 짜릿함은 잊을 수가 없어요. 이런 과정들이 즐거워서 저는 앞으로도 계속 연구하게 될 것 같습니다. 4. 이 분야로 진학하려는 후배들 또는 유학준비생들에게 도움이 되는 말씀을 해 주신다면?
- Cell Reports
- 2023.01.16
Subtle visual change in a virtual environment induces heterogeneous remapping systematically in CA1, but not CA3
- Cell Reports VOLUME 41, ISSUE 11, 111823, DEC 13, 2022 | https://doi.org/10.1016/j.celrep.2022.111823
- 2022.12
- 바이오·의료융합
In vivo fate and intracellular trafficking of vaccine delivery systems
- Adv. Drug Deliv. Rev. Available online 10 May 2022 | https://doi.org/10.1016/j.addr.2022.114325
- 2022.05
- 의약학
- 박성범(서울대학교)
  Interview
- 이인아(서울대학교 뇌인지과학과)
The fasciola cinereum subregion of the hippocampus is important for the acquisition of visual contextual memory
- Prog. Neurobiol. Volume 210, March 2022, 102217 | https://doi.org/10.1016/j.pneurobio.2022.102217
- 2022.03
- 바이오·의료융합
- 김상훈(University of Pennsylvania)
Flexible encoding of objects and space in single cells of the dentate gyrus
- Curr. Biol. Volume 32, Issue 5, 14 March 2022, Pages 1088-1101.e5 | https://doi.org/10.1016/j.cub.2022.01.023
- 2022.03
- 바이오·의료융합
Olatunji Ajiteru

한림대학교 의과대학

You recently published a paper, in the journal “Biofabrication, (2021)”, titled “A digital light processing 3D printed magnetic bioreactor system using silk magnetic bioink”. Can you please briefly summarize this paper? Can you please tell us the main difficulties you had in the laboratory work and how you overcome them? The paper, digital light processing 3D printed magnetic bioreactor using silk magnetic bioink detailed the fabrication and application of an easy to operate magnetic bioreactor with magneto responsive hydrogel. In the study, a biocompatible 3D-printed magnetic hydrogel was developed with a good adaptation of mechanical strength induced by magnetic force produced by a magnetic bioreactor. The magnetic part of the hydrogel was manufactured by adding iron oxide (IO) to Silk-GMA, and the cellular part of the hydrogel was printed with gelatin glycidyl methacrylate (Gel-GMA) by DLP 3D printer using a continuous one-stage layering technique to produce a single composite hydrogel. The cell-encapsulated magnetic hydrogel was cultured in the magnetic bioreactor, manufactured by DLP printing using resin, that supplied uniaxial repetitive magneto-mechanical stimulus without direct contact with the scaffolds. We discovered that the magnetic bioreactor induced the proliferation and multiple myogenic gene expressions of skeletal muscle cells in the 3D-bioprinted scaffold. In the future, the magnetic bioreactor system can offer diverse magneto mechanical forces to cells in 3D settings, investigating approaches to improve differentiation of various cells. The differentiated Gel-GMA encapsulated cells can be detached from the magnetic part with a scalpel and implanted for further in vivo studies. The major difficulty I have while working on this project is the construction of the electric circuit and writing of codes for the magnetic bioreactor system. My major has been medical science so it’s difficult working in an electronic circuit related field.
- Biofabrication
- 2022.02.03
Nanda Maya Mali

경북대학교 의과대학

1. 논문관련 분야의 소개, 동향, 전망을 설명, 연구과정에서 생긴 에피소드 Lineage tracing provides information about the number of progenies of the founder cell, their growing pattern and differentiation status. Recently, many lineage tracing approaches have been developed to track a cellular lineage in diverse cells, tissues and whole organisms. The early processes in embryogenesis have been studied in the model organisms using direct observation. The complete developmental cellular lineage of C. elegans was reconstructed by using the microscopic observation, leading this study awarded the Nobel Prize in 2002 (Sulston et al. 1983, Dev Biol). After then, many researchers have used direct observation approach for studying cellular lineages during embryogenesis in zebrafish (Kimmel CB and Warga RM. 1986, Science) and fruit-fly (Campos-Ortega and Hartenstein. 1985, Springer-Verlag Berlin Heidelberg) by developing different microscopic techniques. Recently, genetically modified mice (such as Brainbow mice and Confetti mice etc.) have also become the mainstream of genetic lineage tracing studies, using Cre-loxP and FLP-FRT systems (Livet et al. 2007, Nature; Snippert et al. 2010, Cell). These technologies have been used for the expression of the fluorescent proteins or polylox cassette (excisions and inversions), also used as genetic barcode to study the clonal output, cellular diversity and tissues during embryonic development, cell differentiation and tissue regeneration (Pei et al. 2017, Nature). In addition, CRISPR-Cas9 barcode editing approach with single cell sequencing and genome editing of synthetic target arrays for lineage tracing (GESTALT) technique in animal models (Yang et al. 2014, Nat Commun; McKenna et al. 2016, Science) have been developed for elucidating accurate lineage trees for the early embryonic developmental stages. A new CRISPR based cancer cell lineage tracing method offers to trace real time cancer progression across thousands of
- Nature
- 2021.09.16
- Balachandran Manavalan(아주대학교)
- 이광(아주대학교)
Computational prediction of species-specific yeast DNA replication origin via iterative feature representation
- Brief. Bioinform. Volume 22, Issue 4, July 2021, bbaa304, https://doi.org/10.1093/bib/bbaa304
- 2021.07
- 의약학
- 진승우(서울대학교)
  Interview
- 이인아(서울대학교)
Differential encoding of place value between the dorsal and intermediate hippocampus
- Curr. Biol. Available online 27 May 2021 | https://doi.org/10.1016/j.cub.2021.04.073
- 2021.05
- 바이오·의료융합