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통합검색

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'neuromuscular disorders' 에 대한 통합검색결과 14건입니다.

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- 이웅휘(University of California, San Francisco)
A unifying mechanism for presynaptic homeostatic plasticity at mammalian peripheral and central synapses
- Neuron June 30, 2025 | https://www.cell.com/neuron/fulltext/S0896-6273(25)00430-1
- 2025.06
- 생명과학
- 김원진(성균관대학교)
- 김근형(성균관대학교 의과대학 정밀의학교실)
Bioprinting 3D muscle tissue supplemented with endothelial-spheroids for neuromuscular junction model
- Appl. Phys. Rev. Vol 10, Issue 3 Sep 2023 | https://doi.org/10.1063/5.0152924
- 2023.09
- 바이오·의료융합
최석진

서울대학교병원

루게릭병은 뇌와 척수의 운동신경세포가 사멸되어 발병 2-5년만에 사망에 이르는 치명적인 신경퇴행성질환으로 국내 연간 발생 환자는 500여 명, 유병 환자는 3,000여 명으로 추산하고 있습니다. 오래 전부터 신체활동량이 많은 운동선수들에서 루게릭병 발생 빈도가 높고 BMI가 낮은 환자의 예후가 더 나쁘다는 관찰연구들이 있었고, 이에 따라 많은 루게릭병 연구자들이 nutrition 및 metabolism 관련 병인기전에 흥미를 가져왔습니다.
- Ann. Neurol.
- 2023.09.25
Aseer Intisar

DGIST

1. You recently published a paper, in the journal “Biofabrication, (2022) Vol. 14 No. 1 : 015017. doi: 10.1088/1758-5090/ac457c”, titled “An electroceutical approach enhances myelination via upregulation of lipid biosynthesis in the dorsal root ganglion”. - Can you please briefly summarize this paper? - Can you please tell us the main difficulties you had in the laboratory work and how you overcame them? Summary of the paper: Several peripheral demyelinating neuropathies, such as Charcot-Marie-Tooth disease, lack any approved treatment, despite several attempts using pharmacological drugs. One of the major drawbacks of pharmacological drugs is the non-targeted nature of their application. In contrast, electroceuticals are more compatible for targeted application. Furthermore, the electrical impulse matches the communication language of our nervous system. Therefore, we were interested about the potential of electroceuticals to enhance the myelination in the peripheral nervous system (PNS). This work demonstrates the enhancement of myelination via electrical stimulation (ES) in the dorsal root ganglion, an ex vivo model of the PNS. The enhanced myelination resulted from upregulation in lipid biosynthesis and better structural lipid abundance in the myelin membrane. We confirmed the results from immunocytochemistry, RNA-sequencing, qPCR and chemical assays at sequential stages of the myelination process, followed by the analysis of myelin lipids via time-of-flight secondary ion mass spectrometry. In the future, we aim to explore the mechanistic pathways of myelination-enhancing effects of ES in order to recognize its value as translational medicine towards human use. Main difficulties with laboratory work: One of the difficulties was the sensitivity of neuron cells. Since neuron cells are so sensitive, it took a lot of practice to learn the method for handling them. My Bachelor’s degree was not in a biological field, so learning the delicacies
- Biofabrication
- 2022.01.20
- 권영태(Georgia Institute of Technology)
- 여운홍(Georgia Institute of Technology)
Breathable, large-area epidermal electronic systems for recording electromyographic activity during operant conditioning of H-reflex
- Biosens. Bioelectron. Volume 165, 1 October 2020, 112404 | https://doi.org/10.1016/j.bios.2020.112404
- 2020.10
- 바이오·의료융합
- Mithilesh Kumar Jha(경북대학교 의과대학, Johns Hopkins University School of Medicine)
- 석경호(경북대학교 의과대학)
Metabolic reprogramming by the pyruvate dehydrogenase kinase–lactic acid axis: Linking metabolism and diverse neuropathophysiologies
- Neurosci. Biobehav. Rev. Available online 11 May 2016 | doi:10.1016/j.neubiorev.2016.05.006
- 2016.05
- 의약학
- 구진모(The Ohio State University)
An NF-κB - EphrinA5-Dependent Communication between NG2+ Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates
- Dev. Cell Available online 14 January 2016, doi:10.1016/j.devcel.2015.12.018
- 2016.01
- 김홍주(St. Jude Children’s Research Hospital)
- 김남철(St. Jude Children’s Research Hospital)
  Interview
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
- Nature 495, 467–473 (28 March 2013). Published online 03 March 2013 | doi:10.1038/nature11922
- 2013.03
- 생명과학
- 김홍주(St. Jude Children’s Research Hospital)
- 김남철(St. Jude Children’s Research Hospital)
  Interview
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
- Nature 495, 467–473 (28 March 2013). Published online 03 March 2013 | doi:10.1038/nature11922
- 2013.03
- 생명과학
- 제현수(National Institute of Child Health and Human Development, National Institute of Mental Health, Duke-NUS)
Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synaps
- Proc. Natl. Acad. Sci. USA Published online before print September 10, 2012, doi: 10.1073/pnas.1207767109
- 2012.09
- 의약학
- 송용억(Massachusetts Institute of Technology)
- 한종윤(Massachusetts Institute of Technology)
Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes
- Nat. Mater. 10, 980–986 (2011) | Published online23 October 2011 | doi:10.1038/nmat3146
- 2011.10
- 최귀천(University of Texas Medical Branch at Galveston)
Impaired Integrity of DNA after Recovery from Inflammation Causes Persistent Dysfunction of Colonic Smooth Muscle
- Gastroenterology published online 11 July 2011 | doi:10.1053/j.gastro.2011.06.074
- 2011.07
- 김홍균(Rosalind Franklin University of Medicine and Science)
An Alpha-Catulin Homologue Controls Neuromuscular Function through Localization of the Dystrophin Complex and BK Channels in Caenorhabditis elegans
- PLoS Genet. 6(8): e1001077. doi:10.1371/journal.pgen.1001077
- 2010.08
- 김성수(Washington University in St. Louis)
The novel endosomal membrane protein Ema interacts with the class C Vps?HOPS complex to promote endosomal maturation
- J. Cell Biol. vol.188, no.5, 717-734. Published online March 1, 2010. doi:10.1083/jcb.200911126
- 2010.03
- 바이오·의료융합

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