통합검색 | BRIC

통합검색

한빛사

내가 찾은 검색어

1myelination

'myelination' 에 대한 통합검색결과 37건입니다.

한빛사37건

- 이현경(Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute)
Daam2 phosphorylation by CK2α negatively regulates Wnt activity during white matter development and injury
- Proc. Natl. Acad. Sci. USA 2023 Aug 29;120(35):e2304112120 | https://doi.org/10.1073/pnas.2304112120
- 2023.08
- 의약학
Cdon ablation in motor neurons causes age-related motor neuron degeneration and impaired sciatic nerve repair
- J. Cachexia Sarcopenia Muscle 2023 Aug 09 | https://doi.org/10.1002/jcsm.13308
- 2023.08
- 의약학
- 문선영(분당서울대학교병원)
- 권준수(서울대학교 의과대학)
Magnetic resonance texture analysis reveals stagewise nonlinear alterations of the frontal gray matter in patients with early psychosis
- Mol. Psychiatr. Published: 27 July 2023 | https://doi.org/10.1038/s41380-023-02163-3
- 2023.07
- 바이오·의료융합
- 김지영(The Ohio State University)
Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury
- Kidney Int. 2023 Jun;103(6):1093-1104 | https://doi.org/10.1016/j.kint.2023.02.026
- 2023.06
Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice
- Nat. Commun. 2023 Feb 13;14(1):802 | https://doi.org/10.1038/s41467-023-36519-8
- 2023.02
- 생명과학
Computational conjugate adaptive optics microscopy for longitudinal through-skull imaging of cortical myelin
- Nat. Commun. 2023 Jan 6;14(1):105 | https://doi.org/10.1038/s41467-022-35738-9
- 2023.01
- 바이오·의료융합
Adaptive autophagy reprogramming in Schwann cells during peripheral demyelination
- Cell. Mol. Life Sci. 2023 Jan 9;80(1):34 | https://doi.org/10.1007/s00018-022-04683-7
- 2023.01
- 의약학
Electroceutical approach ameliorates intracellular PMP22 aggregation and promotes pro-myelinating pathways in a CMT1A in vitro model
- Biosens. Bioelectron. Available online 30 December 2022 | https://doi.org/10.1016/j.bios.2022.115055
- 2022.12
- 바이오·의료융합
- Aseer Intisar(DGIST)
- 김민석(DGIST)
Implantable Electroceutical Approach Improves Myelination by Restoring Membrane Integrity in a Mouse Model of Peripheral Demyelinating Neuropathy
- Adv. Sci. First published: 17 August 2022 | https://doi.org/10.1002/advs.202201358
- 2022.08
- 바이오·의료융합
- Aseer Intisar(DGIST)
  Interview
- 김민석(DGIST)
An electroceutical approach enhances myelination via upregulation of lipid biosynthesis in the dorsal root ganglion
- Biofabrication Published 6 January 2022 | https://doi.org/10.1088/1758-5090/ac457c
- 2022.01
- 바이오·의료융합
Aseer Intisar

DGIST

1. You recently published a paper, in the journal “Biofabrication, (2022) Vol. 14 No. 1 : 015017. doi: 10.1088/1758-5090/ac457c”, titled “An electroceutical approach enhances myelination via upregulation of lipid biosynthesis in the dorsal root ganglion”. - Can you please briefly summarize this paper - Can you please tell us the main difficulties you had in the laboratory work and how you overcame them Summary of the paper: Several peripheral demyelinating neuropathies, such as Charcot-Marie-Tooth disease, lack any approved treatment, despite several attempts using pharmacological drugs. One of the major drawbacks of pharmacological drugs is the non-targeted nature of their application. In contrast, electroceuticals are more compatible for targeted application. Furthermore, the electrical impulse matches the communication language of our nervous system. Therefore, we were interested about the potential of electroceuticals to enhance the myelination in the peripheral nervous system (PNS). This work demonstrates the enhancement of myelination via electrical stimulation (ES) in the dorsal root ganglion, an ex vivo model of the PNS. The enhanced myelination resulted from upregulation in lipid biosynthesis and better structural lipid abundance in the myelin membrane. We confirmed the results from immunocytochemistry, RNA-sequencing, qPCR and chemical assays at sequential stages of the myelination process, followed by the analysis of myelin lipids via time-of-flight secondary ion mass spectrometry. In the future, we aim to explore the mechanistic pathways of myelination-enhancing effects of ES in order to recognize its value as translational medicine towards human use. Main difficulties with laboratory work: One of the difficulties was the sensitivity of neuron cells. Since neuron cells are so sensitive, it took a lot of practice to learn the method for handling them. My Bachelor’s degree was not in a biological field, so learning the delicacies
- Biofabrication
2022.01.20
2022.01.20
Fluroxypyr-1-methylheptyl ester interferes with the normal embryogenesis of zebrafish by inducing apoptosis, inflammation, and neurovascular toxicity
- Comp. Biochem. Physiol. C-Toxicol. Pharmacol. Available online 27 April 2021.
- 2021.04
- 생명과학
- 김기표(가톨릭대학교 의과대학, Max Planck Institute for Molecular Biomedicine)
  Interview
Donor-cell memory and transgene-mediated off-targets endow metastable state to directly converted cells
- Cell Stem Cell Published:April 12, 2021 | https://doi.org/10.1016/j.stem.2021.02.023
- 2021.04
- 의약학
형수진

서울대학교

1. 논문관련 분야의 소개, 동향, 전망을 설명, 연구과정에서 생긴 에피소드 미세유체칩을 이용한 삼차원 세포배양기술은 오래 전부터 활발히 진행되고 있는 연구 분야입니다. 특히 미세유체칩에 말초신경시스템의 구조 및 기능을 모사하는 것은 복잡한 신경계의 세포간 상호작용을 분석할 수 있는 이점이 있어 신경 재생을 극복하고 메커니즘을 분석하기 위한 효율적인 방법으로 각광받고 있습니다. 현재 미세유체칩을 활용한 말초신경계 연구는 신경의 발달 단계 또는 손상 단계에 초점을 맞춘 연구가 중점적으로 진행되고 있습니다. 본 연구는 말초운동신경계를 이루는 motor neuron과 Schwann cell의 reciprocal communication을 발달 단계부터 손상, 그리고 다시 재생 단계에 이르기까지 full spectrum을 재현한 연구입니다. 특히 약물에 의해 de-myelination과 re-myelination 형성을 유도하여 말초운동신경계의 대표 질환인, 길랑-바레증후군(Guillain-Barre syndrome, GBS), 다발성경화증, 만성 염증성 탈수초성 다발신경병증 같은 demyelination-related disease을 모델링 하였습니다. 이 과정에서 cell morphology, myelin-related protein expression, intracellular calcium, myelin structure 등 다양한 분석을 통하여 말초신경병증 검증하고 약물에 의한 재생을 monitoring하였습니다. 본 연구를 통해 효율적인 약물 스크리닝과 다각적 세포간 reciprocal interplay을 이해할 수 있는 새로운 모델을 제시하였으며, translational medicine의 새로운 tool로 적용할 수 있을 것으로 기대됩니다. 2. 연구를 진행했던 소속기관 또는 연구소에 대해 소개 부탁 드립니다. 본 연구는 서울대학교 기계공학부 전누리교수님 연구실에서 진행하였습니다. 전누리교수님 연구실은 biomimetic 소재를 이용한 미세유체칩을 개발하고, 이를 바이오 분야에 활용하기 위한 연구를 활발히 진행하고 있습니다. 특히 인체 내 장기나 혈관 조직을 모사한 organ-on-a-chip을 개발하고 질병 모델을 구축하여, 질병의 메커니즘이나 약물 스크리닝 등의 연구를 진행하고 있습니다. 전누리 교수님께서는 자기 주도적으로 연구 방향을 설정하고 진행할 수 있도록 전폭적으로 지원을 해주시며, 연구실 구성원들과의 활발한 교류를 통해 공학과 바이오 분야에 대한 전문적인 지식을 습득하고, 연구 주제에 대한 다양한 관점과 이해를 경험
- Sci. Adv.
2021.02.23
2021.02.23
A 3D disease and regeneration model of peripheral nervous system-on-a-chip
- Sci. Adv. 29 Jan 2021: Vol. 7, no. 5, eabd9749 | DOI: 10.1126/sciadv.abd9749
- 2021.01
- 양승민(Harvard University)
Neuron class?specific responses govern adaptive myelin remodeling in the neocortex
- Science 18 Dec 2020: Vol. 370, Issue 6523, eabd2109 | DOI: 10.1126/science.abd2109
- 2020.12
- 유승완(The Johns Hopkins University School of Medicine)
Inhibition of neutral sphingomyelinase 2 promotes remyelination
- Sci. Adv. 02 Oct 2020: Vol. 6, no. 40, eaba5210 | DOI: 10.1126/sciadv.aba5210
- 2020.10
Electrically Conductive Hydrogel Nerve Guidance Conduits for Peripheral Nerve Regeneration
- Adv. Funct. Mater. First published: 12 August 2020 | https://doi.org/10.1002/adfm.202003759
- 2020.08
- 바이오·의료융합
- 이현경(Baylor College of Medicine)
The Daam2?VHL?Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation
- Genes Dev. Published in Advance August 13, 2020 | 10.1101/gad.338046.120
- 2020.08
- 의약학
- 양현식(Harvard Medical School)
  Interview
Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology
- Neuron Published:June 10, 2020 | https://doi.org/10.1016/j.neuron.2020.05.010
- 2020.06
- 의약학