통합검색

한빛사

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1memory deficit

'memory deficit' 에 대한 통합검색결과 20건입니다.

한빛사20건

최신순
관련도순

- 함아롬(Columbia University Irving Medical Center)
Synaptic and cognitive impairment associated with L444P heterozygous glucocerebrosidase mutation
- Brain Nov 20 2024, awae380 | https://doi.org/10.1093/brain/awae380
- 2024.11
- 의약학
Effects and safety of transcranial direct current stimulation on multiple health outcomes: an umbrella review of randomized clinical trials
- Mol. Psychiatr. 30 May 2024 | https://doi.org/10.1038/s41380-024-02624-3
- 2024.05
- 바이오·의료융합
Association of Sleep Disturbances With Brain Amyloid and Tau Burden, Cortical Atrophy, and Cognitive Dysfunction Across the AD Continuum.
- Neurology Oct 09 2023 | https://doi.org/10.1212/WNL.0000000000207917
- 2023.10
- 의약학
High-fat diet-induced dopaminergic dysregulation induces REM sleep fragmentation and ADHD-like behaviors
- Psychiatry Res. Vol 327, Sep 2023, 115412 | https://doi.org/10.1016/j.psychres.2023.115412
- 2023.09
- 의약학
- 김청섭(Medical College of Georgia at Augusta University)
Glucocorticoid-glucocorticoid receptor-HCN1 channels reduce neuronal excitability in dorsal hippocampal CA1 neurons
- Mol. Psychiatr. Published 15 July 2022 | https://doi.org/10.1038/s41380-022-01682-9
- 2022.07
- 의약학
- 황홍익(Massachusetts Institute of Technology, 한국과학기술연구원)
Neurogranin, encoded by the schizophrenia risk gene NRGN, bidirectionally modulates synaptic plasticity via calmodulin-dependent regulation of the neu
- Biol. Psychiatry Available online 29 July 2020 | https://doi.org/10.1016/j.biopsych.2020.07.014
- 2020.07
- 생명과학
- 한성(University of Washington)
Dissecting the phenotypes of Dravet syndrome by gene deletion
- Brain First published online: 27 May 2015 | doi:10.1093/brain/awv142
- 2015.05
- 생명과학
- 이지석(KAIST)
- 김은준(KAIST, 기초과학연구원)
Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit
- Front. Cell. Neurosci. Published: 19 March 2015 | https://doi.org/10.3389/fncel.2015.00094
- 2015.03
- 생명과학
- 한성(University of Washington)
  Interview
Autistic-like behaviour in Scn1a+/− mice and rescue by enhanced GABA-mediated neurotransmission
- Nature 489, 385–390 (20 September 2012). Published online22 August 2012 | doi:10.1038/nature11356
- 2012.08
- 생명과학
- 한성(University of Washington)
  Interview
Autistic-like behaviour in Scn1a+/− mice and rescue by enhanced GABA-mediated neurotransmission
- Nature 489, 385–390 (20 September 2012). Published online22 August 2012 | doi:10.1038/nature11356
- 2012.08
- 생명과학
- 전병탁(경상대학교)
- 노구섭(경상대학교 의과대학)
Resveratrol Attenuates Obesity-Associated Peripheral and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet
- Diabetes Volume 61, Issue 6, June 2012, Pages 1444-1454 | https://doi.org/10.2337/db11-1498
- 2012.06
- 의약학
PI3Kγ is required for NMDA receptor–dependent long-term depression and behavioral flexibility
- Nat. Neurosci. 14, 1447–1454 (2011) | Published online23 October 2011 | doi:10.1038/nn.2937
- 2011.10
- 생명과학
- 이용석(University of California, Los Angeles)
[News and Views]Modeling hyperactivity: of mice and men
- Nat. Med. Volume: 17, 541-542, (2011) | doi:10.1038/nm0511-541
- 2011.05
- 생명과학
GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice
- Nat. Med. 17, 566–572 (2012) | Published online 17 April 2011 | doi:10.1038/nm.2330
- 2011.04
- 생명과학
정지혜

University of California at San Diego

1. Background and significance of the current study Major depressive disorder (MDD), or depression is one of the leading causes of psychiatric disability in the United States and worldwide. Even though the risk for depression is highly genetic, the search for "depression genes" has been difficult, likely due to the multifaceted nature of depressive disorders. In addition to possible genetic components, there appears to be an environmental component in the neurobiology of MDD. This reinforces the idea that depression is a combination of genetic and environmental factors. Among various hypotheses regarding the etiology of depressive disorder, the theory suggests that modifications in monoaminergic neurotransmission are instrumental in the pathophysiology and treatment of depression. Anatomically, the lateral habenula (LHb), a part of the epithalamus, is quite unique since it projects to the all the major monoamine centers in the brain such as the ventral tegmental area (VTA, dopamine center), dorsal raphe nucleus (DRN, serotonin center), as well as locus coeruleus (LC, norepinephrine center). These distinctive projections make the LHb a very strong candidate area of interest to study pathophysiology of depression. In this study, we focused on the LHb projection to the dopamine center, VTA, which controls reward-seeking behavior. In two well-established animal models of depression, the synaptic activity of LHb neurons that project to the VTA is remarkably potentiated in the helpless animals compared to the control na?ve animals, as if the LHb may act as a "disappointment center." The LHb is known to suppress the activity of the VTA, the main source of a reward signal, dopamine. So, the activation of the LHb, in turn, reduces dopamine release from the VTA, therefore animal feels dissatisfaction or disappointment. So one can picture that the hyperactivity in the LHb observed in the helpless animals, therefore, perhaps serves as higher expectation for positive events, t
- Nature
- 2011.03.08
- 박성진(Johns Hopkins University School of Medicine)
- 박주민(Johns Hopkins University School of Medicine)
Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD
- Neuron Vol 59, 70-83, 10 July 2008
- 2008.07
- 의약학
- 박성진(Johns Hopkins University School of Medicine)
- 박주민(Johns Hopkins University School of Medicine)
Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD
- Neuron Vol 59, 70-83, 10 July 2008
- 2008.07
- 의약학
- 유승식(Harvard Medical School)
A deficit in the ability to form new human memories without sleep
- Nat. Neurosci. 10, 385 - 392 (2007). Published online: 11 February 2007 | doi:10.1038/nn1851
- 2007.02
- 유승식(Harvard Medical School)
A deficit in the ability to form new human memories without sleep
- Nat. Neurosci. 10, 385 - 392 (2007). Published online: 11 February 2007 | doi:10.1038/nn1851
- 2007.02
- 황대연(식품의약품안전청 )
- 김용규(식품의약품안전청)
Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer‘‘s disease.
- FASEB J. 2002 Jun;16(8):805-13
- 2002.06