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'hearing loss' 에 대한 통합검색결과 69건입니다.

한빛사69건

최신순
관련도순

홍지원

연세대학교 의과대학, 현 NIH

현대 사회에 들어서면서 다양한 환경 소음의 증가로 인해 소음성 난청(noise induced hearing loss, NIHL)의 유병률은 지속적으로 증가하고 있습니다. 조류와 달리 포유류에서는 한 번 손상된 청력은 자연적으로 회복되지 않는 것으로 알려져 있어, 소음성 난청은 대표적인 비가역적 감각 신경 질환으로 인식되고 있습니다.
- Proc. Natl. Acad. Sci. USA
- 2026.02.06
Pharmacological chaperones mitigate noise-induced hearing loss by attenuating sustained PERK activation
- Proc. Natl. Acad. Sci. USA Jan 27 2026, 123 (4) | https://doi.org/10.1073/pnas.2421591123
- 2026.01
- 생명과학
Heavy metal exposure and all health outcomes: an umbrella review of meta-analyses
- J. Hazard. Mater. Available online 13 January 2026, 141141 | https://doi.org/10.1016/j.jhazmat.2026.141141
- 2026.01
- 바이오·의료융합
TMEM145 is a key stereociliary component in the link structures of outer hair cells and mediates the secretion of stereocilin and tubby
- Nat. Commun. 01 December 2025 | https://doi.org/10.1038/s41467-025-67011-0
- 2025.12
- 생명과학
Gene supplementation with precise transgene expression rescues hearing loss in a mouse model with an Mpzl2 East Asian founder variant
- Mol. Ther. Oct 06 2025, S1525-0016(25)00826-3 | https://doi.org/10.1016/j.ymthe.2025.10.005
- 2025.10
- 의약학
Antisense oligonucleotide therapy mitigates autosomal dominant progressive hearing loss in a murine model of human DFNA2
- Mol. Ther. Sep 02 2025, S1525-0016(25)00718-X | https://doi.org/10.1016/j.ymthe.2025.08.044
- 2025.09
- 의약학
Engineered virus-like particles for in vivo gene editing ameliorate hearing loss in murine DFNA2 model
- Mol. Ther. Sep 02 2025, S1525-0016(25)00723-3 | https://doi.org/10.1016/j.ymthe.2025.08.049
- 2025.09
- 의약학
Self-degradable prodrug thermogel: A new injectable formulation for efficient and safe inner ear therapy
- Chem. Eng. J. Volume 519, 1 September 2025 | https://doi.org/10.1016/j.cej.2025.164947
- 2025.09
- 바이오·의료융합
PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation
- Nat. Commun. Published: 05 August 2025;16,7186 (2025) | https://doi.org/10.1038/s41467-025-62562-8
- 2025.08
- 생명과학
배한규

University of Michigan

SCN2A 유전자는 Voltage gated sodium channel 1.2 (Nav1.2)를 발현하는 유전자로, 다양한 신경발달장애(neurodevelopmental disorders)와 밀접한 관련이 있습니다. 특히 SCN2A의 기능 변화 양상에 따라 서로 다른 질환이 유발되는데, gain of function (GOF) 변이는 주로 간질(epilepsy)과 연관되어 있으며, loss of function (LOF) 변이는 자폐 스펙트럼 장애(ASD)와 밀접하게 관련되어 있는 것으로 알려져 있습니다.
- Nat. Commun.
- 2025.08.07
- 김위한(Keck School of Medicine of University of Southern California)
Human inner ear fluid imbalance detected by optical coherence tomography correlates with hearing loss
- Sci. Transl. Med. Jul 23 2025, 17 (808) | https://doi.org/10.1126/scitranslmed.adv3783
- 2025.07
- 바이오·의료융합
- 최한슬(연세대학교 의과대학)
- 복진웅(연세대학교 의과대학)
SHANK2 establishes auditory hair bundle architecture essential for mammalian hearing
- Proc. Natl. Acad. Sci. USA Jul 15 2025, 122 (28) | https://doi.org/10.1073/pnas.2426646122
- 2025.07
- 의약학
Comprehensive genetic profiling of sensorineural hearing loss using an integrative diagnostic approach
- Cell Rep. Med. June 30, 2025 | https://doi.org/10.1016/j.xcrm.2025.102206
- 2025.06
- 김도형(울산대학교 의과대학, 서울아산병원)
- 정준민(울산대학교 의과대학, 서울아산병원)
Ocular and Auditory Comorbidities in Patients with Vitiligo: A Nationwide Population-Based Study in the Republic of Korea
- J. Am. Acad. Dermatol. Jun 21 2025, S0190-9622(25)02377-1 | https://doi.org/10.1016/j.jaad.2025.06.047
- 2025.06
- 이지윤(Boston Children’s Hospital, Harvard Medical School)
Generation and characterization of vestibular inner ear organoids from human pluripotent stem cells
- Nat. Protoc. Jun 02 2025, | https://doi.org/10.1038/s41596-025-01191-3
- 2025.06
Systematic genetic assessment of hearing loss using whole-genome sequencing identifies pathogenic variants
- Exp. Mol. Med. Apr 01 2025, | https://doi.org/10.1038/s12276-025-01428-x
- 2025.04
- 의약학
Shh agonist enhances maturation in homotypic Lgr5-positive inner ear organoids
- Theranostics Published 2025-4-13; 15(12):5543-5565 | doi:10.7150/thno.107345
- 2025.04
- 생명과학
나타니엘 카르페나

단국대학교

Our research aimed to address a long-standing challenge in hearing loss therapy: how to generate functional cochlear hair cells in the lab. These cells are responsible for converting sound vibrations into electrical signals that the brain can interpret. In humans, once these cells are damaged-due to aging, noise, or drugs-they do not regenerate.
- Theranostics
- 2025.04.28
Injectable polyplex-loaded glycol chitosan thermogel for efficient and safe inner ear gene delivery
- J. Control. Release Feb 20 2025, S0168-3659(25)00173-7 | https://doi.org/10.1016/j.jconrel.2025.02.060
- 2025.02
- 바이오·의료융합
MYH1 deficiency disrupts outer hair cell electromotility, resulting in hearing loss
- Exp. Mol. Med. 01 November 2024 | https://doi.org/10.1038/s12276-024-01338-4
- 2024.11
- 의약학