통합검색 | BRIC

통합검색

한빛사

내가 찾은 검색어

1glomerulonephritis

'glomerulonephritis' 에 대한 통합검색결과 8건입니다.

한빛사8건

최신순
관련도순

Macrophage transcription factor TonEBP promotes systemic lupus erythematosus and kidney injury via damage-induced signaling pathways
- Kidney Int. 2023 Jul;104(1):163-180 | https://doi.org/10.1016/j.kint.2023.03.030
- 2023.07
- 생명과학
The oxidative phosphorylation inhibitor IM156 suppresses B-cell activation by regulating mitochondrial membrane potential and contributes to the mitig
- Kidney Int. Available online 1 November 2022 | https://doi.org/10.1016/j.kint.2022.09.031
- 2022.11
- 의약학
Kidney VISTA prevents IFN-γ/IL-9 axis?mediated tubulointerstitial fibrosis after acute glomerular injury
- J. Clin. Invest. Published: January 4, 2022, 132(1):e151189 | https://doi.org/10.1172/JCI151189
- 2022.01
- 의약학
- 조진현(인하대학교 의과대학, 인하대학교병원)
- 안명주(성균관대학교 의과대학, 삼성서울병원)
Pembrolizumab for Patients With Refractory or Relapsed Thymic Epithelial Tumor: An Open-Label Phase II Trial
- J. Clin. Oncol. Published online before print June 15, 2018 | https://doi.org/10.1200/JCO.2017.77.3184
- 2018.06
- 의약학
- 류희주(서울대학교)
  Interview
- 정연석(서울대학교)
Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27
- Nat. Immunol. Published: 30 April 2018 | doi:10.1038/s41590-018-0102-6
- 2018.04
- 생명과학
- 황정민(University of Utah)
In Situ Imaging of Tissue Remodeling with Collagen Hybridizing Peptides
- ACS Nano Publication Date (Web): September 6, 2017 | DOI: 10.1021/acsnano.7b03150
- 2017.09
심길진

Karolinska Institute

1. Introduction for our recent findings Over 100 years ago, it was noted that more women than men were affected by autoimmune diseases including Sjögren's syndrome (SS), systemic lupus erythematosus and rheumatoid arthritis. SS is a predominantly female, incurable, autoimmune exocrinopathy whose pathogenesis remains unknown. It is one of the most common autoimmune disease with 2 million patients in USA. SS is best characterized by lymphocytic infiltration into and destruction of the salivary gland but it is, associated interstitial cystitis and lymphoma. Thus a significant percent of SS patients develop lymphoid malignancies. We have investigated one model of estrogen deficiency, the aromatase knockout (Ar-/-) mouse and report here that estrogen deficiency results in an immune disorder, distinct from autoimmune nephritis, found in ERa -/- mice (Shim et al. PNAS 2004) and myeloid leukemia found in ERb -/- mice (Shim et al. PNAS 2003, reviewed Nature Cancer Review 2003 ). Life time loss of estrogen causes spontaneous development of SS without pre-conditioning. Like in the human disease, we found severe destruction of salivary glands, and lymphocytic infiltration into the kidney, hepato-biliary system, lung and pancreas. Also we found estrogen treatment could rescue one indication of SS in Ar-/- mice thus the disease seems to be reversible. Moreover wild type mice fed phytoestrogen-free diet for a year showed clearly higher incidence of SS, than their littermates on a normal diet. Our finding indicates that phytoestrogens in the diet can reduce the incidence of SS and that one early event in SS can be inhibited by treatment with estrogen. It is a very important key to our understanding of the role of estrogen in the immune system that three different genetic models of estrogen deficiency result in three different diseases of the immune system. Although it has been known for 100 years that estrogen is responsible for the high incidence of autoimm
- Proc. Natl. Acad. Sci. USA
- 2004.08.16
- 심길진(Karolinska Institute)
Autoimmune glomerulonephritis with spontaneous formation of splenic germinal centers in mice lacking the estrogen receptor alpha gene
- Proc. Natl. Acad. Sci. USA Published online before print January 26, 2004.
- 2004.01

1