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1electroceuticals

'electroceuticals' 에 대한 통합검색결과 7건입니다.

한빛사7건

Needle-like Multifunctional Biphasic Microfiber for Minimally Invasive Implantable Bioelectronics
- Adv. Mater. Jun 06 2024, | https://doi.org/10.1002/adma.202404101
- 2024.06
- 바이오·의료융합
Electroceuticals for Regeneration of Long Nerve Gap Using Biodegradable Conductive Conduits and Implantable Wireless Stimulator
- Adv. Sci. 2023 Jun 20;e2302632 | https://doi.org/10.1002/advs.202302632
- 2023.06
- 의약학
Aseer Intisar

DGIST

1. Can you please briefly summarize this paper? ?Summary of the paper: Charcot-Marie-Tooth (CMT) disease is one of the most prevalent demyelinating peripheral neuropathies worldwide, affecting nearly 3 million people. The most common subtype of CMT disease is CMT1A, caused by the duplication of the PMP22 gene in Schwann cells (SCs). Unfortunately, previous biochemical approaches have not resulted in an approved treatment for CMT1A disease, compelling the pursuit for a biophysical approach such as electroceuticals. However, the effects of electroceuticals on CMT1A in vitro had remained unexplored. In this study, we demonstrated that electrical stimulation (ES) can ameliorate CMT1A-associated biomolecular abnormalities using PMP22-overexpressed Schwannoma cells, an in vitro CMT1A model. We carried out screening for the optimal ES frequency using a custom-made HTS platform, and found that 20 Hz ES for 1 hr resulted in the optimal beneficial changes, such as: (i) amelioration of intracellular PMP22 aggregation and improved distribution in the cell membrane, (ii) upregulation in the expression of genes encoding myelin proteins, and (iii) inducing pro-myelinating regulatory pathways. This study revealed key biomolecular changes in CMT1A SCs resulting from electroceuticals, and will hopefully play a crucial role in the clinical translation of an electroceutical-based treatment for CMT1A disease. 2. Please introduce your laboratory, university or organization to bio-researchers in Korea. ?I am currently an integrated MS/PhD student in the BioDr Lab in the Department of New Biology at DGIST. Our specialization includes multidisciplinary research fields such as stimulation biology (e.g., electroceuticals), centrifugal microfluidics, organ-on-a-chip, and cancer diagnostics/therapeutics. Among these topics, I am working with the application of electroceuticals towards intractable diseases, as well as trying to develop a non-invasive interface for electroceut
- Biosens. Bioelectron.
- 2023.01.17
Electroceutical approach ameliorates intracellular PMP22 aggregation and promotes pro-myelinating pathways in a CMT1A in vitro model
- Biosens. Bioelectron. Available online 30 December 2022 | https://doi.org/10.1016/j.bios.2022.115055
- 2022.12
- 바이오·의료융합
- 맹우열(고려대학교)
- 구자현(고려대학교)
Electroceuticals for peripheral nerve regeneration
- Biofabrication Published 8 September 2022 8;14(4). | doi: 10.1088/1758-5090/ac8baa
- 2022.09
- 바이오·의료융합
- Aseer Intisar(DGIST)
  Interview
- 김민석(DGIST)
An electroceutical approach enhances myelination via upregulation of lipid biosynthesis in the dorsal root ganglion
- Biofabrication Published 6 January 2022 | https://doi.org/10.1088/1758-5090/ac457c
- 2022.01
- 바이오·의료융합
Aseer Intisar

DGIST

1. You recently published a paper, in the journal “Biofabrication, (2022) Vol. 14 No. 1 : 015017. doi: 10.1088/1758-5090/ac457c”, titled “An electroceutical approach enhances myelination via upregulation of lipid biosynthesis in the dorsal root ganglion”. - Can you please briefly summarize this paper? - Can you please tell us the main difficulties you had in the laboratory work and how you overcame them? Summary of the paper: Several peripheral demyelinating neuropathies, such as Charcot-Marie-Tooth disease, lack any approved treatment, despite several attempts using pharmacological drugs. One of the major drawbacks of pharmacological drugs is the non-targeted nature of their application. In contrast, electroceuticals are more compatible for targeted application. Furthermore, the electrical impulse matches the communication language of our nervous system. Therefore, we were interested about the potential of electroceuticals to enhance the myelination in the peripheral nervous system (PNS). This work demonstrates the enhancement of myelination via electrical stimulation (ES) in the dorsal root ganglion, an ex vivo model of the PNS. The enhanced myelination resulted from upregulation in lipid biosynthesis and better structural lipid abundance in the myelin membrane. We confirmed the results from immunocytochemistry, RNA-sequencing, qPCR and chemical assays at sequential stages of the myelination process, followed by the analysis of myelin lipids via time-of-flight secondary ion mass spectrometry. In the future, we aim to explore the mechanistic pathways of myelination-enhancing effects of ES in order to recognize its value as translational medicine towards human use. Main difficulties with laboratory work: One of the difficulties was the sensitivity of neuron cells. Since neuron cells are so sensitive, it took a lot of practice to learn the method for handling them. My Bachelor’s degree was not in a biological field, so learning the delicacies
- Biofabrication
- 2022.01.20

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