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Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis
- PLoS Med. Published December 30, 2020 | https://doi.org/10.1371/journal.pmed.1003501
- 2020.12
- 의약학
Xingshu Li

이화여자대학교, Fuzhou University

1. You recently published a paper, in the journal "ACS Nano, (2017)", titled "Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy". - Can you please briefly summarize this paper? Response: In this study, we devised a new strategy that relies on an activatable supramolecular approach to improve photodynamic therapy (PDT). In our design, a unique phthalocyanine photosensitizer (PcS) and an anthracenedione based antineoplastic drug (MA) are employed as a host and guest for assembly of uniform nanostructures (PcS-MA). Studies show that PcS-MA not only display nanoscale optical properties but also they have a nucleic acid-activation capability. In vivo evaluations indicate that PcS-MA have a high level of accumulation in tumor tissues, and that they can be used for light-up imaging of cancer cells. More significantly, PcS-MA display improved photodynamic anticancer behavior owing to the synergistic effects of photothermal therapy and chemotherapy. We believe that this study will attract the interest of researchers engaged in cancer therapy and that it will provide a novel perspective for designing supramolecular theranostic agents. - Can you please tell us the main difficulties you had in the laboratory work and how you overcame them? Response: One of the main difficulty may be the screening of appropriate host and guest molecules for the fabrication of nano-assemblies. This part of work took me about 2 years when I was a Ph.D. student under the guidance of my supervisor (Prof. Jian-Dong Huang) at Fuzhou University. Another difficulty may be the mouse experiment, which requires enough experience and also takes lots of time. This part of work was cooperated with Prof. Ki Taek Nam's group at Yonsei University. Here, I would like to thank them for their kindness, and also thank for the assistance from Ms. Dayoung Lee (Ph. D candidate) and Ms. Gyoungmi Kim at Ewha Womans University. At last, I w
- ACS Nano
- 2018.01.15
- 윤우현(Duke University)
Nova2 Interacts with a Cis-Acting Polymorphism to Influence the Proportions of Drug-Responsive Splice Variants of SCN1A
- Am. J. Hum. Genet. 80:876-883, 2007
- 2007.04
- 이세진(The Johns Hopkins University School of Medicine)
Regulation of muscle growth by multiple ligands signaling through activin type II receptors
- Proc. Natl. Acad. Sci. USA Published online before print December 5, 2005
- 2005.12

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