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통합검색

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'Systems Biology' 에 대한 통합검색결과 771건입니다.

한빛사771건

최신순
관련도순

RiboJ-assisted non-repeated sgRNA arrays for enhanced CRISPR multiplex genome engineering in Escherichia coli
- Chem. Eng. J. Volume 512, 15 May 2025, 162336 | https://doi.org/10.1016/j.cej.2025.162336
- 2025.05
- 생명과학
허광범

Stanford University School of Medicine

우리 몸의 에너지 생산 공장이라고 잘 알려진 미토콘드리아는 꽤 다양한 경로를 통해 많은 세포 활동에 영향을 미칩니다. 본 연구는 그 중에서도 미토콘드리아 구조 변화(mitochondrial dynamics)에 관한 것입니다. 미토콘드리아는 필요에 따라 분열하거나 서로 융합하여 세포 항상성을 유지합니다.
- Nat. Commun.
- 2025.05.13
- 전병훈(한양대학교)
Unraveling the genetic basis of microbial metal resistance: Shift from mendelian to systems biology
- J. Hazard. Mater. Apr 21 2025, 493 S0304-3894(25)01265-8 | https://doi.org/10.1016/j.jhazmat.2025.138350
- 2025.04
- 생명과학
DDX54 downregulation enhances anti-PD1 therapy in immune-desert lung tumors with high tumor mutational burden
- Proc. Natl. Acad. Sci. USA Apr 08 2025, 122 (14) | https://doi.org/10.1073/pnas.2412310122
- 2025.04
- 생명과학
Self-supervised machine learning framework for high-throughput electron microscopy
- Sci. Adv. Apr 04 2025, 11 (14) eads5552 | https://doi.org/10.1126/sciadv.ads5552
- 2025.04
나타니엘 카르페나

단국대학교

Our research aimed to address a long-standing challenge in hearing loss therapy: how to generate functional cochlear hair cells in the lab. These cells are responsible for converting sound vibrations into electrical signals that the brain can interpret. In humans, once these cells are damaged-due to aging, noise, or drugs-they do not regenerate.
- Theranostics
- 2025.04.28
Sana Abdul Khaliq

가천대학교 의과대학

In this study, we investigated how a protein called ARHGEF3 regulates fat cell (adipocyte) development and enlargement?two key processes involved in obesity. We discovered that ARHGEF3 plays a dual role: it helps fat cells grow in size through the YAP-RhoA signaling pathway, and it promotes their full differentiation by boosting the activity of PPARγ, a master regulator of fat cell development.
- J. Adv. Res.
- 2025.04.26
- 손민준(University of Chicago)
Macrophage memory emerges from coordinated transcription factor and chromatin dynamics
- Cell Syst. February 11, 2025 | https://doi.org/10.1016/j.cels.2025.101171
- 2025.02
- 허우녕(Duke University School of Medicine, 현 The Rockefeller University & Memorial Sloan Kettering Cancer Center)
  Interview
Topological interactions drive the first fate decision in the Drosophila embryo
- Nat. Phys. 25 February 2025 | https://doi.org/10.1038/s41567-025-02796-x
- 2025.02
- 생명과학
Exosome-Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering
- Small Methods Feb 25 2025, | https://doi.org/10.1002/smtd.202402058
- 2025.02
- 바이오·의료융합
- 홍주형(한양대학교)
- 김용희(한양대학교)
Cutting-edge biotherapeutics and advanced delivery strategies for the treatment of metabolic dysfunction-associated steatotic liver disease spectrum
- J. Control. Release Feb 11 2025, 380 S0168-3659(25)00114-2 | https://doi.org/10.1016/j.jconrel.2025.02.008
- 2025.02
- 바이오·의료융합
Zinah Hilal Khaleel

성균관대학교

1. Can you please briefly summarize the paper? This article details the design of a photoswitchable organic–peptide hybrids that self-associate into Ca 2+ -binding dimers when exposed to specific light wavelengths. This research highlights the potential of photoswitchable compounds to regulate complex equilibria, enabling the design of photoactive systems. These findings could lead to applications in various fields, demonstrating the ability to control protein behavior with light and targeted metal in this case calcium. 2. Can you please tell us the main difficulties you had in the laboratory work and how you overcame them? One of the main challenges I faced during my laboratory work was maintaining motivation, especially when progress felt slow or results were elusive. To overcome this, I learned to pause and reflect on how far I’d come, which helped me regain perspective and stay focused. Another difficulty was dealing with unexpected or unfavorable results. When experiments didn’t go as planned, I focused on being constructive evaluating whether the data could still be useful or identifying lessons to improve future work. There were also moments when I realized my research direction needed adjustment. Instead of seeing this as a setback, I embraced flexibility, adapted my approach, and found new ways to move forward. Finally, time management was a constant challenge. I worked on setting realistic goals, avoiding overloading my schedule, and accepting that some time pressure is inherent to the process. These strategies helped me stay productive and resilient throughout my PhD journey. 3. Please introduce your laboratory, university or organization to bio-researchers in Korea. I worked at the YH Protein Design Laboratory, a cutting-edge research group focused on protein engineering and design. The lab specializes in developing innovative approaches to understand, predict, and manipulate protein structures and functions, with applications rangin
- Proc. Natl. Acad. Sci. USA
- 2025.02.14
Cell-free systems: A synthetic biology tool for rapid prototyping in metabolic engineering
- Biotechnol. Adv. Available online 23 January 2025, 108522 | https://doi.org/10.1016/j.biotechadv.2025.108522
- 2025.01
- 생명과학
이정호

Ghent University

Bio-based long-chain dicarboxylic acids (LCDAs) are in high demand in the polymer industry. These compounds have diverse applications as building blocks for polymers with distinct features, which lead to a fast-growing global LCDA market. However, bio-based LCDA production is currently limited in Europe as established processes are using the pathogenic yeast, Candida tropicalis.
- Bioresour. Technol.
- 2025.01.14
Control of Cellular Differentiation Trajectories for Cancer Reversion
- Adv. Sci. Dec 11 2024, | https://doi.org/10.1002/advs.202402132
- 2024.12
- 생명과학
Advanced MicroRNA delivery for lung inflammatory therapy: surfactant protein A controls cellular internalisation and degradation of extracellular vesi
- Thorax Dec 04 2024, thorax-2024-221793 | https://doi.org/10.1136/thorax-2024-221793
- 2024.12
- 생명과학
옴미 파와

순천향대학교 의과대학

Biodegradable metals, notably magnesium alloys, are emerging as promising materials for cranial bone reconstruction due to their biodegradability. The biodegradable properties and exceptional mechanical strength of magnesium alloys make them superb materials for cranial bone reconstruction procedures.
- J. Magnes. Alloy.
- 2024.12.26
- 문태석(J. Craig Venter Institute)
Producing multiple chemicals through biological upcycling of waste poly(ethylene terephthalate)
- Trends Biotechnol. Nov 23 2024, S0167-7799(24)00309-3 | https://doi.org/10.1016/j.tibtech.2024.10.018
- 2024.11
- 생명과학
Proteogenomic analysis reveals non-small cell lung cancer subtypes predicting chromosome instability, and tumor microenvironment
- Nat. Commun. Nov 23 2024, 15 (1) | https://doi.org/10.1038/s41467-024-54434-4
- 2024.11
- 의약학
A molecular perspective on the role of FERONIA in root growth, nutrient uptake, stress sensing and microbiome assembly
- J. Adv. Res. Nov 04 2024, S2090-1232(24)00494-6 | https://doi.org/10.1016/j.jare.2024.11.002
- 2024.11
- 생명과학