한빛사40건

• • 강희민(고려대학교)

  Multimodal biomedical utility of polyaniline-based supramolecular nanomaterials

  • Chem. Eng. J. Available online 24 May 2024 | https://doi.org/10.1016/j.cej.2024.15253

  • 2024.05
  • 바이오·의료융합
• 

  이아라

  POSTECH

  우리 몸의 세포는 복잡한 시스템 속에서 서로 소통하며 생명을 유지합니다. 특히 세포 내 여러 소기관 사이의 소통은 칼슘과 지질 등의 생체분자교환, 항상성 조절, 자가포식작용 등 다양한 세포 기전을 매개하며 중요한 역할을 하고 있습니다. 이러한 소기관 소통은 서로 다른 소기관 사이의 막접촉부위(Membrane Contact Site, MCS)에서 역동적으로 움직이는 단백질들에 의해 주로 매개되기 때문에, 다양한 생명 현상과 그 기전의 이해를 위해서는 해당 단백질의 분석이 필수적입니다.

  • Nat. Commun.
  • 2024.04.02

• • 김지현(고려대학교)

  • 김종승(고려대학교)

  Engineered Metallacycle-Based Supramolecular Photosensitizers for Effective Photodynamic Therapy

  • Angew. Chem.-Int. Edit. 2023 Apr 3;62(15):e202301560 | https://doi.org/10.1002/anie.202301560

  • 2023.04
  • 바이오·의료융합

• • 김상필(UNIST)

  • Batakrishna Jana(UNIST)

  • 고은민(UNIST)

  • 진준오(영남대학교)

  • 곽상규(UNIST)

  • 유자형(UNIST)

  Intramitochondrial Disulfide Polymerization Controls Cancer Cell Fate

  • ACS Nano Publication Date:September 3, 2021 | https://doi.org/10.1021/acsnano.1c04015

  • 2021.09
  • 바이오·의료융합

• • Sumit Kumar(UNIST)

  • 조윤경(UNIST, IBS)

  Programmed exosome fusion for energy generation in living cells

  • Nat. Catal. Published 13 September 2021 | https://doi.org/10.1038/s41929-021-00669-z

  • 2021.09
  • 바이오·의료융합

• • 구재형(IBS, POSTECH)

  • 김익진(IBS, POSTECH)

  • 백무현(IBS, KAIST)

  • 김기문(IBS, POSTECH)

  Gigantic Porphyrinic Cages

  • Chem Available online 27 October 2020 | https://doi.org/10.1016/j.chempr.2020.10.002

  • 2020.10
  • 바이오·의료융합

• • 김인혜(광주과학기술원, 충남대학교)

  • 이은지(광주과학기술원)

  Supramolecular Carbon Monoxide‐Releasing Peptide Hydrogel Patch

  • Adv. Funct. Mater. First published: 25 September 2018 | https://doi.org/10.1002/adfm.201803051

  • 2018.09
  • 바이오·의료융합

• • Meng Li(기초과학연구원)

  • 이아라(POSTECH)

    Interview

  • 박경민(기초과학연구원)

  • 김기문(POSTECH, 기초과학연구원, UST)

  Autophagy Caught in the Act: A Supramolecular FRET Pair Based on an Ultrastable Synthetic Host–Guest Complex Visualizes Autophagosome–Lyso

  • Angew. Chem.-Int. Edit. Version of Record online: 25 JAN 2018 | DOI: 10.1002/anie.201711629

  • 2018.01
  • 바이오·의료융합

• • 박경민(기초과학연구원, UST)

  • 김기문(POSTECH, 기초과학연구원)

  Mono-allyloxylated Cucurbit[7]uril Acts as an Unconventional Amphiphile to Form Light-responsive Vesicles

  • Angew. Chem.-Int. Edit. Accepted manuscript online: 29 JAN 2018, DOI: 10.1002/anie.201713059

  • 2018.01
  • 바이오·의료융합
• 

  Xingshu Li

  이화여자대학교, Fuzhou University

  1. You recently published a paper, in the journal "ACS Nano, (2017)", titled "Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy". - Can you please briefly summarize this paper? Response: In this study, we devised a new strategy that relies on an activatable supramolecular approach to improve photodynamic therapy (PDT). In our design, a unique phthalocyanine photosensitizer (PcS) and an anthracenedione based antineoplastic drug (MA) are employed as a host and guest for assembly of uniform nanostructures (PcS-MA). Studies show that PcS-MA not only display nanoscale optical properties but also they have a nucleic acid-activation capability. In vivo evaluations indicate that PcS-MA have a high level of accumulation in tumor tissues, and that they can be used for light-up imaging of cancer cells. More significantly, PcS-MA display improved photodynamic anticancer behavior owing to the synergistic effects of photothermal therapy and chemotherapy. We believe that this study will attract the interest of researchers engaged in cancer therapy and that it will provide a novel perspective for designing supramolecular theranostic agents. - Can you please tell us the main difficulties you had in the laboratory work and how you overcame them? Response: One of the main difficulty may be the screening of appropriate host and guest molecules for the fabrication of nano-assemblies. This part of work took me about 2 years when I was a Ph.D. student under the guidance of my supervisor (Prof. Jian-Dong Huang) at Fuzhou University. Another difficulty may be the mouse experiment, which requires enough experience and also takes lots of time. This part of work was cooperated with Prof. Ki Taek Nam's group at Yonsei University. Here, I would like to thank them for their kindness, and also thank for the assistance from Ms. Dayoung Lee (Ph. D candidate) and Ms. Gyoungmi Kim at Ewha Womans University. At last, I w

  • ACS Nano
  • 2018.01.15

• • Xingshu Li(이화여자대학교, Fuzhou University)

    Interview

  • 유성숙(연세대학교 의과대학)

  • 이다영(이화여자대학교)

  • 남기택(연세대학교 의과대학)

  • 윤주영(이화여자대학교)

  Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy

  • ACS Nano Publication Date (Web): December 12, 2017 | DOI: 10.1021/acsnano.7b07809

  • 2017.12
  • 의약학

• • 이성수(Northwestern University, 현 Stanford University)

    Interview

  Sulfated glycopeptide nanostructures for multipotent protein activation

  • Nat. Nanotechnol. Published online 19 June 2017 | doi:10.1038/nnano.2017.109

  • 2017.06

• • 백상열(성균관대학교)

  • 방창현(성균관대학교)

  A wet-tolerant adhesive patch inspired by protuberances in suction cups of octopi

  • Nature 546, 396-400 (15 June 2017) | doi:10.1038/nature22382

  • 2017.06
  • 바이오·의료융합

• • 박치영(한국과학기술연구원)

  Signal-Induced Release of Guests from a Photolatent Metal–Phenolic Supramolecular Cage and Its Hybrid Assemblies

  • Angew. Chem.-Int. Edit. Volume 56, Issue 20, pages 5485-5489, May 8, 2017 | DOI: 10.1002/anie.201701152

  • 2017.05

• • 박경민(기초과학연구원, UST)

  • James Murray(기초과학연구원)

  • 김기문(기초과학연구원, POSTECH)

  [Commentarty]Ultrastable Artificial Binding Pairs as a Supramolecular Latching System: A Next Generation Chemical Tool for Proteomics

  • Acc. Chem. Res. Publication Date (Web): March 21, 2017 | DOI: 10.1021/acs.accounts.6b00645

  • 2017.03
  • 바이오·의료융합

• • 김용주(Jilin University)

  • 이명수(Jilin University)

  Collective helicity switching of a DNA–coat assembly

  • Nat. Nanotechnol. Published online 27 March 2017 | doi:10.1038/nnano.2017.42

  • 2017.03
  • 바이오·의료융합

• • James Murray(기초과학연구원)

  • 심재환(POSTECH)

  • Dinesh Shetty(기초과학연구원)

  • 김기문(POSTECH)

  Enrichment of Specifically Labeled Proteins by an Immobilized Host Molecule

  • Angew. Chem.-Int. Edit. Volume 56, Issue 9, pages 2395–2398, February 20, 2017 | DOI: 10.1002/anie.201611894

  • 2017.02
  • 바이오·의료융합

• • 홍봉진(Northwestern University)

  Enhancing DNA-Mediated Assemblies of Supramolecular Cage Dimers through Tuning Core Flexibility and DNA Length—A Combined Experimental–Mod

  • J. Am. Chem. Soc. Publication Date (Web): September 23, 2015 | DOI: 10.1021/jacs.5b08678

  • 2015.09

• • 김영은(KAIST)

  • 정용원(KAIST)

  Green fluorescent protein nanopolygons as monodisperse supramolecular assemblies of functional proteins with defined valency

  • Nat. Commun. Published 14 May 2015, 6, Article number: 7134 | doi:10.1038/ncomms8134

  • 2015.05
  • 바이오·의료융합

• • 김종승(고려대학교)

  Chromogenic/Fluorogenic Ensemble Chemosensing Systems

  • Chem. Rev. Publication Date (Web): May 12, 2015, 115 (15), pp 7893-7943, DOI: 10.1021/cr500553d

  • 2015.05