한빛사155건

• • 김훈(중앙대학교)

  • 문성권(중앙대학교)

  Pharmacological effects of biologically synthesized ginsenoside CK-rich preparation (AceCK40) on the colitis symptoms in DSS-induced Caco-2 cells and

  • Phytomedicine Volume 124, February 2024, 155301 | https://doi.org/10.1016/j.phymed.2023.155301

  • 2024.02

• • 이기범(Rutgers, The State University of New Jersey)

  Enhancing CAR Macrophage Efferocytosis via Surface Engineered Lipid Nanoparticles Targeting LXR Signaling

  • Adv. Mater. Feb 14 2024, | https://doi.org/10.1002/adma.202308377

  • 2024.02
  • 바이오·의료융합

• • 박용국(University of Massachusetts Amherst)

    Interview

  • 이정우(University of Massachusetts Amherst)

  Functional and analytical recapitulation of osteoclast biology on demineralized bone paper

  • Nat. Commun. 07 December 2023 | https://doi.org/10.1038/s41467-023-44000-9

  • 2023.12
  • 생명과학

• • 정수민(기초과학연구원, 연세대학교)

  • 신욱진(기초과학연구원)

  • 전영욱(University of California, San Francisco)

  • 곽민석(연세대학교)

  • 천진우(연세대학교)

  Hydrogel Magnetomechanical Actuator Nanoparticles for Wireless Remote Control of Mechanosignaling In Vivo

  • Nano Lett. 2023 May 16 | https://doi.org/10.1021/acs.nanolett.3c01207

  • 2023.05
  • 바이오·의료융합

• • 윤성희(Harvard Medical School)

  A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis

  • J. Clin. Invest. 2023 May 1;133(9):e163627 | doi: 10.1172/JCI163627

  • 2023.05

• • 김남희(KAIST)

    Interview

  • 황채영(KAIST, 현(주)아벤티)

  • 조광현(KAIST)

  A cell fate reprogramming strategy reverses epithelial-to-mesenchymal transition of lung cancer cells while avoiding hybrid states

  • Cancer Res. January 11 2023 | https://doi.org/10.1158/0008-5472.CAN-22-1559

  • 2023.01
  • 생명과학
• 

  Aseer Intisar

  DGIST

  1. Can you please briefly summarize this paper? ?Summary of the paper: Charcot-Marie-Tooth (CMT) disease is one of the most prevalent demyelinating peripheral neuropathies worldwide, affecting nearly 3 million people. The most common subtype of CMT disease is CMT1A, caused by the duplication of the PMP22 gene in Schwann cells (SCs). Unfortunately, previous biochemical approaches have not resulted in an approved treatment for CMT1A disease, compelling the pursuit for a biophysical approach such as electroceuticals. However, the effects of electroceuticals on CMT1A in vitro had remained unexplored. In this study, we demonstrated that electrical stimulation (ES) can ameliorate CMT1A-associated biomolecular abnormalities using PMP22-overexpressed Schwannoma cells, an in vitro CMT1A model. We carried out screening for the optimal ES frequency using a custom-made HTS platform, and found that 20 Hz ES for 1 hr resulted in the optimal beneficial changes, such as: (i) amelioration of intracellular PMP22 aggregation and improved distribution in the cell membrane, (ii) upregulation in the expression of genes encoding myelin proteins, and (iii) inducing pro-myelinating regulatory pathways. This study revealed key biomolecular changes in CMT1A SCs resulting from electroceuticals, and will hopefully play a crucial role in the clinical translation of an electroceutical-based treatment for CMT1A disease. 2. Please introduce your laboratory, university or organization to bio-researchers in Korea. ?I am currently an integrated MS/PhD student in the BioDr Lab in the Department of New Biology at DGIST. Our specialization includes multidisciplinary research fields such as stimulation biology (e.g., electroceuticals), centrifugal microfluidics, organ-on-a-chip, and cancer diagnostics/therapeutics. Among these topics, I am working with the application of electroceuticals towards intractable diseases, as well as trying to develop a non-invasive interface for electroceut

  • Biosens. Bioelectron.
  • 2023.01.17

• • 김태경(이화여자대학교)

    Interview

  • 전세진(이화여자대학교, 현 국립안동대학교)

  • 오구택(이화여자대학교)

  2′?5′ oligoadenylate synthetase?like 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability

  • Nat. Commun. 2022 Nov 4;13(1):6647 | doi: 10.1038/s41467-022-34433-z

  • 2022.11
  • 생명과학

• • 노경민(European Molecular Biology Laboratory (EMBL))

  Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements

  • Mol. Syst. Biol. 2022 Aug;18(8):e10473 | https://doi.org/10.15252/msb.202110473

  • 2022.08

• • 최동원(University of Southern California)

  • 홍영권(University of Southern California)

  Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion

  • Circ. Res. July 8, 2022 Vol 131, Issue 2 | https://doi.org/10.1161/CIRCRESAHA.121.320565

  • 2022.07
• 

  Aseer Intisar

  DGIST

  1. You recently published a paper, in the journal “Biofabrication, (2022) Vol. 14 No. 1 : 015017. doi: 10.1088/1758-5090/ac457c”, titled “An electroceutical approach enhances myelination via upregulation of lipid biosynthesis in the dorsal root ganglion”. - Can you please briefly summarize this paper? - Can you please tell us the main difficulties you had in the laboratory work and how you overcame them? Summary of the paper: Several peripheral demyelinating neuropathies, such as Charcot-Marie-Tooth disease, lack any approved treatment, despite several attempts using pharmacological drugs. One of the major drawbacks of pharmacological drugs is the non-targeted nature of their application. In contrast, electroceuticals are more compatible for targeted application. Furthermore, the electrical impulse matches the communication language of our nervous system. Therefore, we were interested about the potential of electroceuticals to enhance the myelination in the peripheral nervous system (PNS). This work demonstrates the enhancement of myelination via electrical stimulation (ES) in the dorsal root ganglion, an ex vivo model of the PNS. The enhanced myelination resulted from upregulation in lipid biosynthesis and better structural lipid abundance in the myelin membrane. We confirmed the results from immunocytochemistry, RNA-sequencing, qPCR and chemical assays at sequential stages of the myelination process, followed by the analysis of myelin lipids via time-of-flight secondary ion mass spectrometry. In the future, we aim to explore the mechanistic pathways of myelination-enhancing effects of ES in order to recognize its value as translational medicine towards human use. Main difficulties with laboratory work: One of the difficulties was the sensitivity of neuron cells. Since neuron cells are so sensitive, it took a lot of practice to learn the method for handling them. My Bachelor’s degree was not in a biological field, so learning the delicacies

  • Biofabrication
  • 2022.01.20

• • 조은정(울산대학교 의과대학, 서울아산병원)

  • 김민서(서울아산병원 의생명연구소)

  • 성창옥(울산대학교 의과대학, 서울아산병원)

  • 장세진(울산대학교 의과대학, 서울아산병원, 온코클루)

  Immuno-genomic classification of colorectal cancer organoids reveals cancer cells with intrinsic immunogenic properties associated with patient surviv

  • J. Exp. Clin. Cancer Res. Published: 13 July 2021, 40, Article number: 230 | https://doi.org/10.1186/s13046-021-02034-1

  • 2021.07
  • 바이오·의료융합

• • 박용국(University of Massachusetts)

    Interview

  • 이정우(University of Massachusetts)

  Trabecular bone organoid model for studying the regulation of localized bone remodeling

  • Sci. Adv. 20 Jan 2021: Vol. 7, no. 4, eabd6495 | DOI: 10.1126/sciadv.abd6495

  • 2021.01

• • 김경호(고려대학교, 충북대학교)

  • 박홍규(고려대학교)

  Structured silicon for revealing transient and integrated signal transductions in microbial systems

  • Sci. Adv. 14 Feb 2020: Vol. 6, no. 7, eaay2760 | DOI: 10.1126/sciadv.aay2760

  • 2020.02
  • 바이오·의료융합

• • 이정원(충북대학교 의과대학)

    Interview

  • 김다미(충북대학교 의과대학)

  • 배석철(충북대학교 의과대학)

  RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point

  • Nat. Commun. Published 23 April 2019, 10, Article number: 1897 | https://doi.org/10.1038/s41467-019-09810-w

  • 2019.04

• • 김지욱(연세대학교, 기초과학연구원)

  • 전영욱(연세대학교, 기초과학연구원, University of California, San Francisco)

  • 천진우(연세대학교, 기초과학연구원)

  Magnetic Nanotweezers for Interrogating Biological Processes in Space and Time

  • Acc. Chem. Res. Publication Date (Web): March 28, 2018 | DOI: 10.1021/acs.accounts.8b00004

  • 2018.03
  • 바이오·의료융합

• • Joseph Jeswin(경상대학교)

  • 주민수(경상대학교)

  • 박찬일(경상대학교)

  The first report of siglec-3/CD33 gene in a teleost (rock bream, Oplegnathus fasciatus): An analysis of its spatial expression during stimulation to r

  • Dev. Comp. Immunol. Available online 7 February 2018, Volume 84, Pages 117-122 | https://doi.org/10.1016/j.dci.2018.02.005

  • 2018.02

• • Joseph Jeswin(경상대학교)

  • 김도형(부경대학교)

  • 박찬일(경상대학교)

  Molecular characterization of a T cell costimulatory receptor, CD28 of rock bream (Oplegnathus fasciatus): Transcriptional expression during bacterial

  • Fish Shellfish Immunol. Available online 3 May 2017 | https://doi.org/10.1016/j.fsi.2017.05.013

  • 2017.05

• • 함돈희(Harvard University)

  • 박홍근(Harvard University)

  CMOS nanoelectrode array for all-electrical intracellular electrophysiological imaging

  • Nat. Nanotechnol. Published online 13 February 2017 | doi:10.1038/nnano.2017.3

  • 2017.02
  • 바이오·의료융합

• • 권재영(성균관대학교)

  A microfluidics-based method for measuring neuronal activity in Drosophila chemosensory neurons

  • Nat. Protoc. Published online 03 November 2016, 11, 2389-2400 | doi:10.1038/nprot.2016.144

  • 2016.11
  • 생명과학