Proteolysis > 통합검색

통합검색

한빛사

내가 찾은 검색어

1Proteolysis

'Proteolysis' 에 대한 통합검색결과 179건입니다.

한빛사179건

최신순
관련도순

An Vuong Quynh Pham

고려대학교

Our research paper worked on elucidating the contribution of dysfunctional blood vessels to manifestation of psoriasis. In this paper, we have shown that, in mural psoriatic lesions, pro-inflammatory cell abundance leads to compromising of blood vessel barrier hence its dysfunctionality.
- Redox Biol.
- 2025.03.04
p21-Activated Kinase 4 and Ischemic Acute Kidney Injury in Mice and Humans
- J. Am. Soc. Nephrol. Feb 28 2025, | https://doi.org/10.1681/ASN.0000000649
- 2025.02
- 의약학
- 홍주형(한양대학교)
- 김용희(한양대학교)
Cutting-edge biotherapeutics and advanced delivery strategies for the treatment of metabolic dysfunction-associated steatotic liver disease spectrum
- J. Control. Release Feb 11 2025, 380 S0168-3659(25)00114-2 | https://doi.org/10.1016/j.jconrel.2025.02.008
- 2025.02
- 바이오·의료융합
Transcriptome analysis of early- and late-onset Alzheimer‘s disease in Korean cohorts
- Alzheimers. Dement. Feb 2025, 21 (2) | https://doi.org/10.1002/alz.14563
- 2025.02
- 의약학
구한

한국생명공학연구원, UST

RAS 단백질은 모든 암종에서 가장 빈번하게 돌연변이가 일어나는 암 유발 단백질 (Oncoprotein) 입니다. 특히 예후가 가장 불량한 암으로 알려져 있는 췌장암은 90% 이상의 KRAS 돌연변이를 수반하며, 돌연변이 KRAS 단백질은 췌장암의 유발 및 진행과정에서 핵심적인 역할을 하는 것으로 잘 알려져 있습니다. 이러한 중요도에도 불구하고, RAS 단백질은 대표적인 ‘표적 불가능한 (Undruggable)’ 단백질로써, 아직까지 임상적으로 성공적인 효과를 거둔 치료제가 개발되지 않고 있는 실정입니다.
- Nat. Commun.
- 2025.02.05
- 박소희(성균관대학교)
- 조홍백(성균관대학교)
A periplasmic protein modulates the proteolysis of peptidoglycan hydrolases to maintain cell wall homeostasis in Escherichia coli
- Proc. Natl. Acad. Sci. USA January 22, 2025 | https://doi.org/10.1073/pnas.2418854122
- 2025.01
- 김찬홍(Chinese Academy of Sciences)
Temperature-driven changes in membrane fluidity differentially impact FILAMENTATION TEMPERATURE-SENSITIVE H2-mediated photosystem II repair
- Plant Cell Dec 12 2024, koae323 | https://doi.org/10.1093/plcell/koae323
- 2024.12
- 생명과학
Self-assembled Peptide-derived Proteolysis-targeting Chimera (PROTAC) Nanoparticles for Tumor-targeted and Durable PD-L1 Degradation in Cancer Immunot
- Angew. Chem.-Int. Edit. Nov 21 2024, | https://doi.org/10.1002/anie.202414146
- 2024.11
- 바이오·의료융합
- 진승모(성균관대학교)
- 임용택(성균관대학교)
Transformable Gel-to-Nanovaccine Enhances Cancer Immunotherapy via Metronomic-Like Immunomodulation and Collagen-Mediated Paracortex Delivery
- Adv. Mater. Oct 09 2024, | https://doi.org/10.1002/adma.202409914
- 2024.10
- 바이오·의료융합
- 송병준(National Institute on Alcohol Abuse and Alcoholism/NIH)
Melatonin Prevents Thioacetamide-Induced Gut Leakiness and Liver Fibrosis Through the Gut-Liver Axis via Modulating Sirt1-Related Deacetylation of Gut
- J. Pineal Res. Sep 2024, 76 (6) | https://doi.org/10.1111/jpi.13007
- 2024.09
UBX-390: A Novel Androgen Receptor Degrader for Therapeutic Intervention in Prostate Cancer
- Adv. Sci. Jul 03 2024, | https://doi.org/10.1002/advs.202400398
- 2024.07
- 생명과학
Light-Triggered PROTAC Nanoassemblies for Photodynamic IDO Proteolysis in Cancer Immunotherapy
- Adv. Mater. Jun 19 2024, | https://doi.org/10.1002/adma.202405475
- 2024.06
- 바이오·의료융합
- Brian Choi(Princeton University)
Cyclic Peptides from Graspetide Biosynthesis and Native Chemical Ligation
- J. Am. Chem. Soc. Apr 18 2024, | https://doi.org/10.1021/jacs.4c02745
- 2024.04
- 남은정(서울대학교)
- 백승렬(서울대학교)
Multifactorial drug carrier system bringing both chemical and physical therapeutics to the treatment of tumor heterogeneity
- J. Control. Release Mar 18 2024, S0168-3659(24)00186-X | https://doi.org/10.1016/j.jconrel.2024.03.033
- 2024.03
- 바이오·의료융합
Control of meiotic crossover interference by a proteolytic chaperone network
- Nat. Plants Feb 20 2024, | https://doi.org/10.1038/s41477-024-01633-y
- 2024.02
- 생명과학
Targeted protein degradation directly engaging lysosomes or proteasomes
- Chem. Soc. Rev. Feb 19 2024, | https://doi.org/10.1039/d3cs00344b
- 2024.02
- 의약학
ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells
- Autophagy Jan 30 2024, | https://doi.org/10.1080/15548627.2024.2305063
- 2024.01
- 의약학
Integrative single-cell transcriptome analysis provides new insights into post-COVID-19 pulmonary fibrosis and potential therapeutic targets
- J. Med. Virol. 2023 Nov;95(11):e29201 | https://doi.org/10.1002/jmv.29201
- 2023.11
- 의약학
박시훈

고려대학교, 현 Friedrich Miescher Institute for Biomedical Research

정상 세포에서는 단백질의 합성, 접힘과 이동, 그리고 분해가 서로 조화롭게 균형을 이루고 있습니다. 이러한 균형을 단백질 항상성 (Proteostasis)이라고 하며, 단백질 항상성이 깨지게 되면 세포는 정상적으로 기능하지 못하고 암, 노화, 신경퇴행성 질환으로 이어지게 됩니다 (William et al., Science 2008). 진핵 세포는 단백질 항상성을 유지하기 위해 표적 단백질에 유비퀴틴 (Ubiquitin) 이라는 작은 단백질 포스트잇을 붙여서 이를 프로테아좀이라는 분해 효소로 제거하는 시스템 (Ubiquitin-Proteasome system)을 갖고 있습니다 (그림1).
- Nat. Struct. Mol. Biol.
- 2023.10.16
- 이동훈(Harvard Medical School)
Molecular mechanism for activation of the 26S proteasome by ZFAND5
- Mol. Cell 2023 Aug 17;83(16):2959-2975.e7 | https://doi.org/10.1016/j.molcel.2023.07.023
- 2023.08