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1Induced pluripotent stem cells

'Induced pluripotent stem cells' 에 대한 통합검색결과 258건입니다.

한빛사258건

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Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs
- Exp. Mol. Med. 06 January 2025 | https://doi.org/10.1038/s12276-024-01375-z
- 2025.01
- 의약학
- 김유리(Harvard Medical School, Brigham and Women’s Hospital)
- 김성원(Harvard Medical School)
Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer
- J. Clin. Invest. Dec 17 2024, e183353 | https://doi.org/10.1172/JCI183353
- 2024.12
Longitudinal analysis of genetic and epigenetic changes in human pluripotent stem cells in the landscape of culture-induced abnormality
- Exp. Mol. Med. 01 November 2024 | https://doi.org/10.1038/s12276-024-01334-8
- 2024.11
In Vitro Modeling of Atherosclerosis Using iPSC-Derived Blood Vessel Organoids
- Adv. Healthc. Mater. 24 November 2024 | https://doi.org/10.1002/adhm.202400919
- 2024.11
- 의약학
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서울대학교 의과대학

저희 연구는 장에서 발생한 신호를 뇌에 전달해줄 수 있는 내장 감각 신경 (Visceral sensory neuron, VSN)을 인간 유도만능 줄기세포 (induced pluripotent stemcell, iPSC)에서 분화시키는 프로토콜을 최초로 만들어 내장 감각 신경절 오가노이드 (Visceral sensory ganglion organoid, VSGO)를 유도하였으며, 이를 iPSC에서 유래한 인간 대장 오가노이드 (Human colon organoid, HCO)와 microfluidic chip에서 연결시켜 Axis-on-a-chip을 만든 뒤, 이를 알츠하이머 질병 모델에 적용하여 알츠하이머의 병리 단백질인 Amyloid beta와 Tau가 VSN을 통해 뇌로 전달될 수 있는 가능성을 in vitro 환경 내에서 입증하였습니다.
- Nat. Methods
- 2024.11.05
Differentiating visceral sensory ganglion organoids from induced pluripotent stem cells
- Nat. Methods 22 October 2024 | https://doi.org/10.1038/s41592-024-02455-8
- 2024.10
- 의약학
Combinational regenerative inductive effect of bio-adhesive hybrid hydrogels conjugated with hiPSC-derived myofibers and its derived EVs for volumetri
- Bioact. Mater. Available online 14 October 2024 | https://doi.org/10.1016/j.bioactmat.2024.09.013
- 2024.10
- 바이오·의료융합
Optimization of culture conditions to generate vascularized multi-lineage liver organoids with structural complexity and functionality
- Biomaterials Oct 18 2024, 314 S0142-9612(24)00432-0 | https://doi.org/10.1016/j.biomaterials.2024.122898
- 2024.10
- 생명과학
Latrophilin-2 Deletion in Cardiomyocyte Disrupts Cell Junction, Leading to D-CMP
- Circ. Res. Oct 18 2024, | https://doi.org/10.1161/CIRCRESAHA.124.324670
- 2024.10
- 의약학
Engineering large-scale hiPSC-derived vessel-integrated muscle-like lattices for enhanced volumetric muscle regeneration
- Trends Biotechnol. Sep 20 2024, S0167-7799(24)00212-9 | https://doi.org/10.1016/j.tibtech.2024.08.001
- 2024.09
- 바이오·의료융합
- 진윤정(Mayo Clinic)
Modeling Lewy body disease with SNCA triplication iPSC-derived cortical organoids and identifying therapeutic drugs
- Sci. Adv. Sep 13 2024, 10 (37) | https://doi.org/10.1126/sciadv.adk3700
- 2024.09
- 조창훈(Genentech, Inc.)
Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism
- Alzheimers. Dement. Aug 01 2024, | https://doi.org/10.1002/alz.13921
- 2024.08
Long-Term Culture of Human Pluripotent Stem Cells in Xeno-Free Condition Using Functional Polymer Films
- Adv. Mater. Jul 17 2024, | https://doi.org/10.1002/adma.202403952
- 2024.07
- 바이오·의료융합
Stepwise dual-release microparticles of BMP-4 and SCF in induced pluripotent stem cell spheroids enhance differentiation into hematopoietic stem cells
- J. Control. Release Available online 8 June 2024 | https://doi.org/10.1016/j.jconrel.2024.06.011
- 2024.06
- 바이오·의료융합
Nanofibril guided spheroid formation for enhanced pluripotency and differentiation of human induced pluripotent stem cells
- Chem. Eng. J. Available online 6 May 2024 | https://doi.org/10.1016/j.cej.2024.151900
- 2024.05
- 바이오·의료융합
Ultrasound-triggered three dimensional hyaluronic acid hydrogel promotes in vitro and in vivo reprogramming into induced pluripotent stem cells
- Bioact. Mater. Available online 9 May 2024 | https://doi.org/10.1016/j.bioactmat.2024.05.011
- 2024.05
- 바이오·의료융합
- 손유라(Mayo Clinic Arizona)
Generation of a Human Induced Pluripotent Stem Cell Line Expressing a Magnetic Resonance Imaging Reporter Gene
- Small Methods May 06 2024, | https://doi.org/10.1002/smtd.202301764
- 2024.05
- 이소아(Stanford University, 성균관대학교)
Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration
- Proc. Natl. Acad. Sci. USA May 07 2024, 121 (19) | https://doi.org/10.1073/pnas.2318413121
- 2024.05
- 박태윤(Harvard Medical School/McLean Hospital)
- 김광수(Harvard Medical School)
Past, present, and future of cell replacement therapy for parkinson‘s disease: a novel emphasis on host immune responses
- Cell Res. May 22 2024, | https://doi.org/10.1038/s41422-024-00971-y
- 2024.05
- 생명과학
Hydroethanolic extract of Cirsium setidens ameliorates doxorubicin-induced cardiotoxicity by AMPK-PGC-1α-SOD-mediated mitochondrial protection
- Phytomedicine Apr 12 2024, 129 S0944-7113(24)00292-7 | https://doi.org/10.1016/j.phymed.2024.155633
- 2024.04
- 생명과학