한빛사36건

• • 황동규(POSTECH)

  • 장진아(POSTECH)

  Bioprinting-assisted Tissue Assembly for Structural and Functional Modulation of Engineered Heart Tissue Mimicking Left Ventricular Myocardial Fiber O

  • Adv. Mater. May 08 2024, | https://doi.org/10.1002/adma.202400364

  • 2024.05
  • 바이오·의료융합
• 

  김성민

  Harvard University

  본 연구는 제가 속한 하버드대 그룹과 빌게이츠 재단의 공동연구로 이뤄졌으며, Sulfadoxine-pyrimethamine이라는 항말리아제를 투여 받은 산모들 (아프리카와 같은 개발도상국 지역)에게서 출산 체중 증가와 산모의 건강증진이라는 효과를 우연히 발견하게 되면서, 잘 알려지지 않은 기존 약물들의 숨겨진 효능을 밝히고자 연구를 시작하게 되었습니다.

  • EBioMedicine
  • 2024.05.02

• • 정해림(서울대학교)

  • 이정환(서울대학교 의과대학, 서울특별시 보라매병원)

  • 이정표(서울대학교 의과대학, 서울특별시 보라매병원)

  • 조성엽(서울대학교 의과대학)

  Targeting the m6A RNA methyltransferase METTL3 attenuates the development of kidney fibrosis

  • Exp. Mol. Med. 01 February 2024 | https://doi.org/10.1038/s12276-024-01159-5

  • 2024.02

• • 이민석(KAIST)

  • 김승규(KAIST)

  • 이태걸(한국표준과학연구원)

  • 임성갑(KAIST)

  • 전성윤(KAIST)

  Hydrophobic surface induced pro-metastatic cancer cells for in vitro extravasation models

  • Bioact. Mater. Available online 8 January 2024 | https://doi.org/10.1016/j.bioactmat.2023.12.021

  • 2024.01
  • 바이오·의료융합

• • 김래현(홍익대학교)

  • 성종환(홍익대학교)

  Recent Advances in Gut- and Gut-Organ-Axis-on-a-Chip Models

  • Adv. Healthc. Mater. Jan 20 2024, | https://doi.org/10.1002/adhm.202302777

  • 2024.01
  • 생명과학

• • 채수정(성균관대학교)

  • 김근형(성균관대학교 의과대학 정밀의학교실)

  Macroscale pseudo-spheroids fabricated using methacrylated collagen-coated cells

  • Theranostics 2024 Jan 1;14(3):924-939 | https://doi.org/10.7150/thno.92193

  • 2024.01
  • 바이오·의료융합

• • 이승희(서울대학교 의과대학)

    Interview

  • 권오상(서울대학교 의과대학 피부과학교실, 서울대학교병원)

  Activation of mitochondrial aldehyde dehydrogenase 2 promotes hair growth in human hair follicles

  • J. Adv. Res. Nov 14 2023, S2090-1232(23)00351-X | https://doi.org/10.1016/j.jare.2023.11.014

  • 2023.11

• • 안민준(부산대학교)

  • 조원우(POSTECH)

  • 김병수(부산대학교)

  3D biofabrication of diseased human skin models in vitro

  • Biomater. Res. 2023 Aug 22;27(1):80 | https://doi.org/10.1186/s40824-023-00415-5

  • 2023.08
  • 바이오·의료융합

• • 최수지(Harvard Univiersity)

  Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles

  • Nat. Mater. 2023 Aug;22(8):1039-1046 | https://doi.org/10.1038/s41563-023-01611-3

  • 2023.08
  • 바이오·의료융합

• • 김덕호(Johns Hopkins School of Medicine)

  Biomanufacturing of 3D Tissue Constructs in Microgravity and their Applications in Human Pathophysiological Studies

  • Adv. Healthc. Mater. 2023 Jul 22;e2300157 | https://doi.org/10.1002/adhm.202300157

  • 2023.07
• 

  Aseer Intisar

  DGIST

  1. Can you please briefly summarize this paper? ?Summary of the paper: Charcot-Marie-Tooth (CMT) disease is one of the most prevalent demyelinating peripheral neuropathies worldwide, affecting nearly 3 million people. The most common subtype of CMT disease is CMT1A, caused by the duplication of the PMP22 gene in Schwann cells (SCs). Unfortunately, previous biochemical approaches have not resulted in an approved treatment for CMT1A disease, compelling the pursuit for a biophysical approach such as electroceuticals. However, the effects of electroceuticals on CMT1A in vitro had remained unexplored. In this study, we demonstrated that electrical stimulation (ES) can ameliorate CMT1A-associated biomolecular abnormalities using PMP22-overexpressed Schwannoma cells, an in vitro CMT1A model. We carried out screening for the optimal ES frequency using a custom-made HTS platform, and found that 20 Hz ES for 1 hr resulted in the optimal beneficial changes, such as: (i) amelioration of intracellular PMP22 aggregation and improved distribution in the cell membrane, (ii) upregulation in the expression of genes encoding myelin proteins, and (iii) inducing pro-myelinating regulatory pathways. This study revealed key biomolecular changes in CMT1A SCs resulting from electroceuticals, and will hopefully play a crucial role in the clinical translation of an electroceutical-based treatment for CMT1A disease. 2. Please introduce your laboratory, university or organization to bio-researchers in Korea. ?I am currently an integrated MS/PhD student in the BioDr Lab in the Department of New Biology at DGIST. Our specialization includes multidisciplinary research fields such as stimulation biology (e.g., electroceuticals), centrifugal microfluidics, organ-on-a-chip, and cancer diagnostics/therapeutics. Among these topics, I am working with the application of electroceuticals towards intractable diseases, as well as trying to develop a non-invasive interface for electroceut

  • Biosens. Bioelectron.
  • 2023.01.17

• • Xiangchun Meng(성균관대학교)

  • 김상우(성균관대학교)

  An Ultrasound-Driven Bioadhesive Triboelectric Nanogenerator for Instant Wound Sealing and Electrically Accelerated Healing in Emergencies

  • Adv. Mater. 2022 Dec 27;e2209054 | https://doi.org/10.1002/adma.202209054

  • 2022.12
  • 바이오·의료융합

• • 심규환(Washington University School of Medicine)

  Cure of disseminated human lymphoma with [177Lu]Lu-ofatumumab in a preclinical model

  • J. Nucl. Med. 2022 Nov 10;jnumed.122.264816 | https://doi.org/10.2967/jnumed.122.264816

  • 2022.11

• • 김현유(Massachusetts Institute of Technology, 현 Stanford University)

  Multiscale engineered human skeletal muscles with perfusable vasculature and microvascular network recapitulating the fluid compartments

  • Biofabrication Published 27 October 2022;15(1) | doi: 10.1088/1758-5090/ac933d

  • 2022.10
  • 의약학

• • 안중호(서울대학교-Georgia Institute of Technology)

  • 김다현(서울대학교)

  • 구동준(서울대학교)

  • 김성연(서울대학교)

  • 김용태(Georgia Institute of Technology)

  • 전누리(서울대학교)

  3D microengineered vascularized tumor spheroids for drug delivery and efficacy testing

  • Acta Biomater. Available online 13 October 2022 | https://doi.org/10.1016/j.actbio.2022.10.009

  • 2022.10
  • 바이오·의료융합

• • 남효영(포항공과대학교)

  • 장진아(POSTECH)

  Modular Assembly of Bioprinted Perfusable Blood Vessel and Tracheal Epithelium for Studying Inflammatory Respiratory Diseases

  • Biofabrication Accepted Manuscript online 21 September 2022 | doi: 10.1088/1758-5090/ac93b6

  • 2022.09
  • 바이오·의료융합

• • 장유진(The University of Texas at Austin)

  • 김종환(The University of Texas at Austin)

  Induction of human trophoblast stem-like cells from primed pluripotent stem cells

  • Proc. Natl. Acad. Sci. USA May 10, 2022, 119 (20) e2115709119 | https://doi.org/10.1073/pnas.2115709119

  • 2022.05
  • 생명과학

• • 윤재승(POSTECH)

  • 홍현준(POSTECH)

  • 김현중(The University of Texas at Austin)

  • 김동성(POSTECH)

  Thin and stretchable extracellular matrix (ECM) membrane reinforced by nanofiber scaffolds for developing in vitro barrier models

  • Biofabrication Published 8 February 2022 | https://doi.org/10.1088/1758-5090/ac4dd7

  • 2022.02
  • 바이오·의료융합

• • 김성진(Texas A&M University)

  Molecular Mechanisms of Environmental Toxin Cadmium at the Feto-Maternal Interface Investigated Using an Organ-On-Chip (FMi-OOC) Model

  • J. Hazard. Mater. Available online 2 August 2021, 126759 | https://doi.org/10.1016/j.jhazmat.2021.126759

  • 2021.08
  • 바이오·의료융합

• • 구자현(한양대학교)

    Interview

  • 최제민(한양대학교 생명과학과)

  Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-κB and inflammasome signaling ac

  • Biomaterials Available online 4 May 2021, 120845 | https://doi.org/10.1016/j.biomaterials.2021.120845

  • 2021.05
  • 생명과학